141018-41-9Relevant academic research and scientific papers
Highly Diastereoselective Alkylations of Chiral Amide Enolates: New Routes to Hydroxyethylene Dipeptide Isostere Inhibitors of HIV-1 Protease
Askin, D.,Wallace, M. A.,Vacca, J. P.,Reamer, R. A.,Volante, R. P.,Shinkai, I.
, p. 2771 - 2773 (2007/10/02)
The nonchelate enforced chiral amide enolates derived from 4-7 react with alkyl iodide and protected α-amino epoxide electrophiles to produce the HIV protease inhibitors 10 and 16-19 with high diastereoselectivity.
