141023-09-8Relevant articles and documents
Facile Synthesis of α-Trifluoromethylated Alcohols from Trifluoroacetaldehyde Ethyl Hemiacetal
Kubota, Toshio,Iijima, Masahiro,Tanaka, Tatsuo
, p. 1351 - 1354 (1992)
Trifluoroacetaldehyde ethyl hemiacetal reacted with nucleophilic organosilanes such as cyanotrimethylsilane, allyltrimethylsilane, or enol trimethylsilyl ethers in the presence of Lewis acid to afford a series of α-trifluoromethylated alcohols in high yield. Key Words: trifluoroacetaldehyde ethyl hemiacetal; Lewis acid; trimethylsilylated nucleophiles; carbon-carbon bond formation; α-trifluoromethylated alcohol.