141030-68-4Relevant articles and documents
HIV-inhibiting benzeneacetamide derivatives
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, (2008/06/13)
A compound for use as a medicine having the formula STR1 a pharmaceutically acceptable acid addition salt form or a stereochemically isomeric form thereof, wherein R1 and R2 each independently are hydrogen, C1-6 alkyl or C3-6 cycloalkyl; or R1 and R2 taken together with the nitrogen atom bearing said R1 and R2 may form a pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl or 4-C1-4 alkylpiperazinyl group; X is O or S; R3 is hydrogen or C1-6 alkyl; R4, R5 and R6 each independently are hydrogen, halo, C1-6 alkyl, C1-6 alkyloxy, nitro, trifluoromethyl, cyano, aminomethyl, carboxyl, C1-4 alkyloxycarbonyl, C1-4 alkyl-carbonyl, aminocarbonyl or hydroxy; R7 is hydrogen or halo; and R8, R9 and R10 each independently are hydrogen, halo, C1-6 alkyl, C1-6 alkyloxy, nitro, hydroxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, (trifluoromethyl)carbonyl, aminocarbonyl, (cyclopropyl)carbonyl or a radical C1-6 alkyl-(C=Y)--wherein =Y represents =O, =N--OH, =N--OCH3, =N--NH2 or =N--N(CH3)2 ; provided that (1) R1 is other than n-propyl when R2, R3, R4, R5, R6, R7, R9 and R10 represent hydrogen, R8 represents 4-ethoxy and X represents oxygen, and (2) X is other than sulfur, when R1, R2, R3, R6, R7, R8, R9 and R10 represent hydrogen and R4 and R5 represent 3,4-dimethoxy. Novel compounds, pharmaceutical compositions containing said compounds of formula (I), and processes for preparing said compositions.
