141036-65-9

Upstream product

• 55941-47-4 4-Phenyl-1-((R)-toluene-4-sulfinyl)-butan-2-ol 
• 96937-97-2 4-Phenyl-1-((R)-toluene-4-sulfinyl)-butan-2-one 
• 96938-00-0 (R)-4-Phenyl-1-((R)-toluene-4-sulfinyl)-butan-2-ol 
• 103-25-3 3-phenylpropanoic acid methyl ester 
• 1519-39-7 (R)-methyl p-tolyl sulfoxide 

Downstream Products

• 141036-66-0 (R)-(2-phenylethyl)oxirane 
• 141036-67-1 (R)-4-Phenyl-1-[2-((E)-styryl)-[1,3]dithian-2-yl]-butan-2-ol 
• 141116-46-3 (-)(R) Yashabushiketol 
• 1126-76-7 1,2-Epoxy-4-phenylbutane 
• 20780-53-4 (R)-Styrene oxide 

Relevant academic research and scientific papers

Asymmetric Synthesis of (-) (R) Yashabushiketol

(-)(R) Yashabushiketol was prepared from the epoxide 4 readily available in both configurations by reduction of β-ketosulfoxides.

REDUCTION OF β-HYDROXYSULFOXIDES: APPLICATION TO THE SYNTHESIS OF OPTICALLY ACTIVE EPOXIDES

β-hydroxysulfoxides of opposite stereochemistry can be prepared in very high diastereoisomeric excesses (90 to 95 percent) by reduction of β-ketosulfoxides with DIBAL or DIBAL/ZnCl2.A very efficient method to transform these reduction products into optically active epoxides is also described.