141046-79-9

Upstream product

• 141046-78-8 methyl 2-(3,5-dichlorophenylamino)-3-methoxycarbonylpropionate 
• 106509-94-8 (E)-2-(3,5-Dichloro-phenylamino)-but-2-enedioic acid dimethyl ester 
• 626-43-7 3,5-Dichloroaniline 

Downstream Products

• 132691-83-9 cis-2-carboxy-4-(carboxymethyl)-5,7-dichloro-1,2,3,4-tetrahydroquinoline 
• 132691-83-9 trans-2-carboxy-4-(carboxymethyl)-5,7-dichloro-1,2,3,4-tetrahydroquinoline 
• 132689-81-7 N-(3,5-Dichloro-phenyl)-N-(2,5-dioxo-tetrahydro-furan-3-yl)-acetamide 

Relevant academic research and scientific papers

Tetrahydroquinoline derivatives useful for neurodegenerative disorders

A class of 1,2,3,4-tetrahydroquinolines possessing at least one substituent, or a spirocyclic moiety, at the 4-position, and an acidic group or a group convertible thereto in vivo at the 2-position, are specific antagonists of N-methyl-D-aspartate (NMDA) receptors and are therefore useful in the treatment and/or prevention of neurodegenerative disorders.

2-Carboxytetrahydroquinolines. Conformational and Stereochemical Requirements for Antagonism of the Glycine Site on the NMDA Receptor

2-Carboxy-1,2,3,4-tetrahydroquinoline derivatives, derived from kynurenic acid, have been synthesized and evaluated for in vitro antagonist activity at the glycine site on the NMDA receptor. 2,3-Dihydrokynurenic acids show reduced potency relative to the