141068-81-7

Basic information

• Product Name: 7-AMINO-4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE
• Synonyms: 7-AMINO-4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE;7-amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one(SALTDATA: FREE);7-AMino-4-Methyl-2H-benzo[b][1,4]oxazin-3(4H)-one
• CAS NO: 141068-81-7
• Molecular Formula: C₉H₁₀N₂O₂
• Molecular Weight: 178.19
• Mol File: 141068-81-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 141-143°
• Boiling Point: 488.5 °C at 760 mmHg
• Flash Point: 249.3 °C
• Appearance: /
• Density: 1.299 g/cm³
• Vapor Pressure: 1.08E-09mmHg at 25°C
• Refractive Index: 1.618
• CAS DataBase Reference: 7-AMINO-4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-AMINO-4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE(141068-81-7)
• EPA Substance Registry System: 7-AMINO-4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE(141068-81-7)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 141068-81-7(Hazardous Substances Data)

Usage

General Description

7-AMINO-4-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE is a chemical compound with the molecular formula C9H8N2O2. It is a derivative of benzoxazinone, which is a naturally occurring compound found in plants. This chemical has potential applications in the field of medicinal chemistry and pharmaceuticals due to its diverse pharmacological properties, including anticancer, anti-inflammatory, and antioxidant activities. The 4-methyl substitution on the benzoxazinone ring may contribute to its unique biological properties, making it a subject of interest for further research and development.

InChI:InChI=1/C9H10N2O2/c1-11-7-3-2-6(10)4-8(7)13-5-9(11)12/h2-4H,5,10H2,1H3

Upstream product

• 141068-80-6 4-methyl-7-nitro-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 81721-86-0 7-nitro-4H-benzo[1,4]oxazin-3-one 

Downstream Products

• 105202-23-1 7-Amino-4-methyl-4H-benzo[1,4]oxazin-3-one; hydrochloride 
• 233775-18-3 (4-methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-carbamic acid benzyl ester 
• 220844-82-6 4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-7-ylamine 

Relevant articles and documents

1-CYANO-PYRROLIDINE DERIVATIVES AS INHIBITORS OF USP30.

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylatingenzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C- terminal hydrolase 30 or Ubiquitin Specific Peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of conditions involving mitochondrial dysfunction and cancer. Compounds of the invention include compounds having the formula (I) (I) or a pharmaceutically acceptable salt thereof, wherein R1, R 2, R 3, m, L and X are as defined herein.

N-aryl-2-oxazolidinone-5-carboxamides and their derivatives

The present invention provides antibacterial agents having the formulae I, II, and III described herein.

6- OR 7-(2-IMINO-2-IMIDAZOLIDINE)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS

Compounds having α adrenergic activity and useful for the treatment of glaucoma, renal and gastrointestinal disorders and vasoconstictors have the formula STR1 where R 1 is independently H, or lower alkyl or 1 to 6 carbons; R 2 is independently H, or lower alkyl of 1 to 6 carbons or the two R 2 symbols jointly represent a carbonyl oxygen; R 3 is H, lower alkyl of one to 6 carbons, O, OH and OR 7 where R 7 is lower alkyl of 1 to 6 carbons, or R 3 is COH or COR 8 where R 8 is lower alkyl of 1 to 6 carbons; R 4 and R 5 independently is H, Br, Cl, or lower alkyl of 1 to 6 carbons, lower alkenyl or lower alkynyl with the proviso that when the R 2 groups symbolize a carbonyl oxygen then R 4 and R 5 both cannot be hydrogen; R 6 is hydrogen, Br, Cl, or lower alkyl of 1 to 6 carbons, lower alkenyl or lower alkynyl, and the R 5 and the (2-imidazoline-2-yl)amino substituents are connected mutually exclusively to the 6 and 7 positions of the 1,4-benzoxazine nucleus.