141072-16-4

Upstream product

• 589-15-1 1-bromomethyl-4-bromobenzene 
• 1729-67-5 Methyl 2,3-dibromopropionate 
• 107047-10-9 p-bromobenzylazide 
• 922-67-8 propynoic acid methyl ester 

Relevant academic research and scientific papers

Highly regioselective and sustainable solar click reaction: A new post-synthetic modified triazole organic polymer as a recyclable photocatalyst for regioselective azide-alkyne cycloaddition reaction

The synthesis of pharmaceutically active 1,2,3-triazoles has been continuously scrutinized in the search for unique and effective catalysts to make the process efficient, green, and sustainable. Here, we are presenting a new visible light active Ni(ii) cyclam-integrated triazole-linked organic polymer (Ni-TLOP) photocatalyst for the synthesis of 1,2,3-triazole compounds with excellent efficiency and regioselectivity. The reaction was studied for a series of substrates and the absolute regioselectivity of a representative triazole product has also been confirmed by X-ray crystallography. The proficiency and chemical orthogonality of the Ni-TLOP are remarkable and it shows enhanced efficiency and regioselectivity. The use of a recyclable photocatalyst and non-hazardous reagents makes the catalytic system sustainable and environmentally friendly. This photocatalyzed click reaction technique has been successfully applied to the expedient synthesis of one of the most sold anti-epileptic drugs rufinamide.

Catalytic cyclization of 2,3-dibromopropionates with benzyl azides to afford 1-benzyl-1,2,3-triazole-4-carboxylate: The use of A nontoxic bismuth catalyst

We synthesized 1,2,3-triazoles via the cyclization of 2,3-dibromopropionates with benzyl azides. Bismuth chloride is an efficient catalyst, and the reaction is accelerated by weak bases such as sodium acetate. A variety of functional groups are compatible

Copper malonamide complexes and their use in azide-alkyne cycloaddition reactions

We report a rare example of the malonamide functionality being used as a ligand in copper catalysis. We have ligated a homologous series of these O,O-chelating architectures to copper, investigated their structure and exploited them in azide-alkyne cycloa

EFFECT OF SOLVENT AND REACTION TIME ON THE PRODUCTS OF THE 1,3-DIPOLAR CYCLOADDITION OF SUBSTITUTED BENZYL AZIDES WITH DI-tert-BUTYL ACETYLENEDICARBOXYLATE

The 1,3-dipolar cycloaddition of substituted benzyl azides with di-tert-butyl acetylenedicarboxylate was found to be sensitive to the solvent (and time) of the reaction.Di-tert-butyl 1,2,3-triazole-4,5-dicarboxylate derivatives were obtained when the reac