1410783-83-3

Basic information

• Product Name: 1-(4-methylbenzyl) 3-ethyl (S)-2-methyl-2-[2-(1,3-dioxoisoindolin-2-yl)ethyl]malonate
• CAS NO: 1410783-83-3
• Molecular Weight: 423.466
• Mol File: 1410783-83-3.mol

Chemical Properties

• CAS DataBase Reference: 1-(4-methylbenzyl) 3-ethyl (S)-2-methyl-2-[2-(1,3-dioxoisoindolin-2-yl)ethyl]malonate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methylbenzyl) 3-ethyl (S)-2-methyl-2-[2-(1,3-dioxoisoindolin-2-yl)ethyl]malonate(1410783-83-3)
• EPA Substance Registry System: 1-(4-methylbenzyl) 3-ethyl (S)-2-methyl-2-[2-(1,3-dioxoisoindolin-2-yl)ethyl]malonate(1410783-83-3)

Safety Data

• Hazardous Substances Data: 1410783-83-3(Hazardous Substances Data)

Upstream product

• 1410783-67-3 (2R)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-(ethoxycarbonyl)-2-methylbutanoic acid 
• 104-81-4 4-Methylbenzyl bromide 
• 609-08-5 Diethyl methylmalonate 
• 14438-67-6 diethyl (+/-)-(2-bromoethyl)methylpropanedioate 

Downstream Products

• 1410783-69-5 ethyl (R)-3-methyl-2-oxopyrrolidine-3-carboxylate 
• 1410783-79-7 C₁₄H₁₇NO₃ 

Relevant articles and documents

A stereoselective cyclization strategy for the preparation of γ-lactams and their use in the synthesis of α-Methyl-β-proline

A straightforward stereoselective and enantiodivergent cyclization strategy for the construction of γ-lactams is described. The cyclization strategy makes use of chiral malonic esters prepared from enantiomerically enriched monoesters of disubstituted malonic acid. The cyclization occurs with the selective displacement of a substituted benzyl alcohol as the leaving group. A Hammett study illustrates that the cyclization is under electronic control. The resulting γ-lactam can be readily converted into a novel proline analogue.