1410787-95-9Relevant academic research and scientific papers
A new approach to steroid dimers and macrocycles by the reaction of 3-chlorocarbonyl derivatives of bile acids with O,O-, N,N-, and S,S-dinucleophiles
Paryzek, Zdzislaw,Joachimiak, Roman,Piasecka, Monika,Pospieszny, Tomasz
, p. 6212 - 6215,4 (2012)
The reaction of 3-chlorocarbonyl derivatives of bile acid esters with O,O-, N,N-, and S,S-dinucleophiles provides a general and efficient entry into steroid dimers with bis-carbamate, bis-carbonate, and bismonothiocarbonate moieties in the linker fragment. The macrocyclization of the bis-carbamate 10 afforded the dimeric and tetrameric cholaphanes, 15 and 16, respectively.
