141080-73-1

Basic information

• Product Name: 4-(BROMOMETHYL)-1-FLUORO-2-METHOXYBENZENE
• Synonyms: 4-FLUORO-3-METHOXYBENZYL BROMIDE;4-(BROMOMETHYL)-1-FLUORO-2-METHOXYBENZENE;3-Methoxy-4-fluorobenzyl bromide;4-(Bromomethyl)-1-fluoro-2-methoxybenzene, 5-(Bromomethyl)-2-fluoroanisole, 5-(Bromomethyl)-2-fluorophenyl methyl ether
• CAS NO: 141080-73-1
• Molecular Formula: C₈H₈BrFO
• Molecular Weight: 219.05
• Product Categories: Methyl Halides;Phenyls & Phenyl-Het;Methyl Halides;Phenyls & Phenyl-Het;Fluorine series
• Mol File: 141080-73-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 252℃
• Flash Point: 126℃
• Appearance: /
• Density: 1.488
• Vapor Pressure: 0.031mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-(BROMOMETHYL)-1-FLUORO-2-METHOXYBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(BROMOMETHYL)-1-FLUORO-2-METHOXYBENZENE(141080-73-1)
• EPA Substance Registry System: 4-(BROMOMETHYL)-1-FLUORO-2-METHOXYBENZENE(141080-73-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 141080-73-1(Hazardous Substances Data)

Usage

General Description

4-(Bromomethyl)-1-fluoro-2-methoxybenzene is a chemical compound with the molecular formula C8H8BrFO. It is a benzene derivative that contains a bromomethyl group, a fluorine atom, and a methoxy group. 4-(BROMOMETHYL)-1-FLUORO-2-METHOXYBENZENE is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals. It may also be used as a reagent in organic synthesis and as a building block in the production of various compounds. Additionally, it has potential applications in the research and development of new materials and chemical processes. Due to its specific chemical structure, it has unique reactivity and potential interactions with other chemicals and biological systems, making it important to handle and use with care.

InChI:InChI=1/C8H8BrFO/c1-11-8-4-6(5-9)2-3-7(8)10/h2-4H,5H2,1H3

Upstream product

• 128495-45-4 (4-fluoro-3-methoxy-phenyl)methanol 
• 128495-46-5 4-fluoro-3-methoxybenzaldehyde 
• 113984-76-2 1-(tert-butyldimethylsilyloxymethyl)-4-fluorobenzene 

Downstream Products

• 872549-98-9 1-[4-fluoro-3-(methyloxy)phenyl]-2-pentanone 

Relevant articles and documents

Synthesis and Biological Evaluation of 1,2,3-triazole tethered Pyrazoline and Chalcone Derivatives

A series of pyrazoline derivatives and corresponding chalcone intermediates with substituents same as combretastatin-A4(CA-4) conjugated with triazole nucleus has been synthesized and evaluated for their anticancer potential. Sulphorhodamine B(SRB) assay indicated compound 12c to be the most active compound from the series with GI50 value of 6.7 μm against the human liver carcinoma cell line HepG2. Interestingly, the intermediate 11c exhibited more promising cytotoxicity demonstrating GI50 value of 1.3 μm against the prostate cancer cell line DU145. Compounds 11c and 12c caused accumulation of cells in G2/M phase and inhibited tubulin polymerization. Furthermore, these compounds reduce the mitochondrial membrane potential and activate caspases 3 and 9, thereby indicating their ability to trigger apoptosis.

Asymmetric synthesis of fluorinated L-tyrosine and meta-L-tyrosines

A convenient asymmetric synthesis of (2S)-2-amino-3-(2-fluoro-5-hydroxyphenyl) propanoic acid, (2S)-2-amino-3-(4-fluoro-3-hydroxyphenyl) propanoic acid and (2S)-2-amino-3-(2-fluoro-4-hydroxyphenyl) propanoic acid is described.Key steps include the synthes