141106-27-6

Basic information

• Product Name: 1-Benzoxepin-5(2H)-one, 3,4-dihydro-8-(4-methylphenyl)-
• CAS NO: 141106-27-6
• Molecular Formula: C17H16O2
• Molecular Weight: 252.313
• Mol File: 141106-27-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Benzoxepin-5(2H)-one, 3,4-dihydro-8-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzoxepin-5(2H)-one, 3,4-dihydro-8-(4-methylphenyl)-(141106-27-6)
• EPA Substance Registry System: 1-Benzoxepin-5(2H)-one, 3,4-dihydro-8-(4-methylphenyl)-(141106-27-6)

Safety Data

• Hazardous Substances Data: 141106-27-6(Hazardous Substances Data)

Upstream product

• 6330-12-7 3-(4-methylphenyl)cyclohex-2-enone 
• 170638-91-2 4-(4'-Methyl-biphenyl-3-yloxy)-butyric acid 

Downstream Products

• 170639-03-9 Heptyl-(8-p-tolyl-2,3,4,5-tetrahydro-benzo[b]oxepin-5-yl)-amine 

Relevant articles and documents

Synthesis and structure-activity relationships of new ACAT inhibitors

A series of heterocyclic ureas were synthesized and their ability to inhibit arterial and intestinal ACAT was assessed in animals.The structural modifications carried out in this series led to N2-(2,4-difluorophenyl)-N1-8-(4-fluorophenyl)-2,3,4,5-tetrahydro-1-benzoxepin-5-yl-N1-n-heptylurea 21, which proved to be very active on both the inhibition of aortic ACAT and the inhibition of rat cholesterol intestinal absorption, thus exhibiting a strong hypocholesterolemic effect po in rat (ED25 = 0.2 mg/kg). aortic ACAT / intestinal inhibition / benzoxepin / urea / cholesterol / hypocholesterolaemic activity