141109-12-8

Basic information

• Product Name: R-Tetrahydropapaverine N-acetyl-L-leucinate
• Synonyms: R-Tetrahydropapaverine N-acetyl-L-leucinate;(R)-1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline N-acetyl-L-leucine;[50896-90-7], C20H25NO4,343.18;1,2,3,4-tetrahydro-6,7-dimethoxy-, (1R);R-Tetrahydropapaverine-N -acety-L-leucinate;N-acetylleucine salt;2-acetamido-4-methylpentanoic acid,1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline;R-Tetrahydropapaverine N-acetyl-L-leucite
• CAS NO: 141109-12-8
• Molecular Formula: C20H25NO4.C8H15NO3
• Molecular Weight: 516.631
• EINECS: 1312995-182-4
• Product Categories: Analgesic series
• Mol File: 141109-12-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: R-Tetrahydropapaverine N-acetyl-L-leucinate(CAS DataBase Reference)
• NIST Chemistry Reference: R-Tetrahydropapaverine N-acetyl-L-leucinate(141109-12-8)
• EPA Substance Registry System: R-Tetrahydropapaverine N-acetyl-L-leucinate(141109-12-8)

Safety Data

• Hazardous Substances Data: 141109-12-8(Hazardous Substances Data)

Usage

Uses

R-Tetrahydropapaverine N-Acetyl-L-leucinate is an intermediate used in the preparation of muscle rellaxant atracurium besylate. it also functions as a useful intermediate in several other organic processes.

Upstream product

• 1188-21-2 N-Ac-Leu 
• 6429-04-5 1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride 
• 19764-30-8 N-acetyl-D-leucine 
• 4747-98-2 S-(-)-Norlaudanosine 

Downstream Products

• 523-02-4 (S)-(-)-norcoralydine 
• 1075727-06-8 (1R,2R)-2-(2-carboxyethyl)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium besylate 
• 1075726-76-9 (1R)-1-[(3,4-dimethoxyphenyl)-methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methoxycarbonylethyl-isoquinoline oxalate 

Relevant articles and documents

Resolution method for tetrahydroisoquinoline compound

The invention provides a resolution method for a tetrahydroisoquinoline compound, specifically to a resolution method for the compound (+/-)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline. A solvent used in the resolution method is w

NOVEL PROCESS FOR THE PREPARATION OF CISATRACURIUM BESYLATE

The present invention is related to a novel process for the preparation of cisatracurium besylate, more particularly optically and geometrically pure cisatracurium besylate in large scale.