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141113-98-6

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141113-98-6 Usage

General Description

4-Bromo-toluene-3-sulfonyl chloride is a chemical compound with the formula C7H6BrClO2S, also known as p-toluenesulfonyl bromide. It is a sulfonyl chloride derivative used in organic synthesis as a mild and selective oxidizing agent and a reagent for the preparation of sulfonamides. It is a colorless to light yellow liquid that is highly reactive and can cause severe skin and eye irritation. 4-BROMO-TOLUENE-3-SULFONYL CHLORIDE is primarily used in pharmaceutical and agrochemical industries for the synthesis of various drugs and pesticides. Additionally, it is used in the production of dyes, pigments, and other specialty chemicals.

Check Digit Verification of cas no

The CAS Registry Mumber 141113-98-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,1,1 and 3 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 141113-98:
(8*1)+(7*4)+(6*1)+(5*1)+(4*1)+(3*3)+(2*9)+(1*8)=86
86 % 10 = 6
So 141113-98-6 is a valid CAS Registry Number.

141113-98-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Bromo-5-methylbenzenesulfonyl chloride

1.2 Other means of identification

Product number -
Other names 4-Brom-toluol-3-sulfonylchlorid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:141113-98-6 SDS

141113-98-6Relevant articles and documents

A scaffold replacement approach towards new sirtuin 2 inhibitors

Seifert, Tina,Malo, Marcus,Kokkola, Tarja,Stéen, E. Johanna L.,Meinander, Kristian,Wallén, Erik A.A.,Jarho, Elina M.,Luthman, Kristina

, (2019/12/24)

Sirtuins (SIRT1–SIRT7) are an evolutionary conserved family of NAD+-dependent protein deacylases regulating the acylation state of ε-N-lysine residues of proteins thereby controlling key biological processes. Numerous studies have found association of the aberrant enzymatic activity of SIRTs with various diseases like diabetes, cancer and neurodegenerative disorders. Previously, we have shown that substituted 2-alkyl-chroman-4-one/chromone derivatives can serve as selective inhibitors of SIRT2 possessing an antiproliferative effect in two human cancer cell lines. In this study, we have explored the bioisosteric replacement of the chroman-4-one/chromone core structure with different less lipophilic bicyclic scaffolds to overcome problems associated to poor physiochemical properties due to a highly lipophilic substitution pattern required for achieve a good inhibitory effect. Various new derivatives based on the quinolin-4(1H)-one scaffold, bicyclic secondary sulfonamides or saccharins were synthesized and evaluated for their SIRT inhibitory effect. Among the evaluated scaffolds, the benzothiadiazine-1,1-dioxide-based compounds showed the highest SIRT2 inhibitory activity. Molecular modeling studies gave insight into the binding mode of the new scaffold-replacement analogues.

Biphenylsulfonyl cyanamides, method for the production thereof and their utilization as a medicament

-

, (2008/06/13)

The invention relates to compounds of the formula (I), in which the symbols have the following meaning: R(1) is 1. alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; 2. alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, in which one to all hydrogen atoms are replaced by fluorine; 3. alkenyl having 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 carbon atoms; or 4. —CnH2n?nn—Y, nn is zero or 2; and n is zero, 1, 2, 3 or 4; where n is unequal to zero or 1 if nn is equal to 2; 5. —CnH2n?nn—Y, nn is zero or 2; and n is 1, 2, 3 or 4; where n is unequal to 1 if nn is equal to 2.

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