14112-12-0Relevant articles and documents
Silver-catalyzed direct addition of terminal alkynes to simple cyclic ketones in water
Jia, Zhenhua,Li, Xingshu,Chan, Alberts. C.,Li, Chao-Jun
, p. 2758 - 2762 (2013/02/21)
The first catalytic addition of terminal alkynes to simple cyclic ketones in water catalyzed by silver was developed. Cyclic ketones were reacted with terminal alkynes efficiently in water to give the corresponding propargyl alcohols. Georg Thieme Verlag
Facile synthesis of dihaloheterocycles via electrophilic iodocyclization
Yang, Fan,Jin, Tienan,Bao, Ming,Yamamoto, Yoshinori
supporting information; scheme or table, p. 10147 - 10155 (2012/01/03)
An efficient and facile electrophilic iodocyclization for the synthesis of various O-, N-, and S-containing dihaloheterocycles has been developed. A wide range of the substituted propargyl alcohols having -OH, -NTs, and -SAc functional groups reacted with molecular iodine or bromoiodine at ambient temperature to produce the corresponding dihalogenated O-, N-, and S-containing five- and six-membered heterocycles in good to high yields; Under optimized solvent conditions, the reactions of various substituted but-2-yn-1-ones bearing -OH, -NTs, and -SAc functional groups at C4-position, with iodine or bromoiodine at ambient temperature afforded the corresponding 3,4-diiodo- and 3-bromo-4-iodo-substituted furans, pyrroles, and thiophenes in good to high yields. Further transformation of the resulting iodine- or bromine-containing products to polyaromatics potentially of useful as organo-material intermediates has been investigated.
