1411565-31-5Relevant articles and documents
Synthesis of 2- and 6-(dialkylaminoalkylthio)- and 2,6- bis(dialkylaminoalkylthio)-7-methylpurines
Kowalska, Alicja,Pluta, Krystian
, p. 2473 - 2483 (2012)
An efficient synthesis of 21 new thiopurines being 2-substituted 6-(dialkylaminoalkylthio)-7-methylpurines, 6-substituted 2- (dialkylaminoalkylthio)- 7-methylpurines, and 2,6-bis(dialkylaminoalkylthio)-7- methylpurines was reported. 2-Substituted 6-(dialkylaminoalkylthio) and 2,6-bis(dialkylaminoalkylthio) derivatives were obtained via direct S-dialkylaminoalkylation of the appro- priate purinethiones. The different reactivities of the dialkylaminalkylthio groups in positions 2 and 6 towards sodium alkoxides were the key processes in a few step synthesis of 2-(dialkylaminoalkylthio) derivatives from 2,6-bis(dialkylaminoalkylthio) derivatives.