141191-07-3

Upstream product

• 141190-99-0 N-Boc-N-methyl-L-phenylalaninal diethylacetal 
• 141190-95-6 N-Boc-L-phenylalaninal diethyl acetal 
• 548-93-6 3-hydroxyanthranilic acid 
• 72155-45-4 Boc-L-phenylalaninal 

Downstream Products

• 141191-19-7 (S)-N-(2-amino-3-hydroxybenzoyl)-N-methyl-1-benzyl-2,2-bis(3'-indolyl)ethylamine 
• 141191-18-6 (2S,3S)-1,2,3,4-tetrahydro-3-benzyl-9-hydroxy-2-(3'-indolyl)-4-methyl-5H-1,4-benzodiazepin-5-one 
• 141270-27-1 (2R,3S)-1,2,3,4-tetrahydro-3-benzyl-9-hydroxy-2-(3'-indolyl)-4-methyl-5H-1,4-benzodiazepin-5-one 

Relevant academic research and scientific papers

SYNTHESIS OF 2-INDOLYL-1,4-BENZODIAZEPIN-5-ONES UTILIZING A MANNICH TYPE CYCLIZATION

2-Indolyl-1,4-benzodiazepin-5-ones (3) have been efficiently synthesized from Boc-α-amino acids (4), 3-hydroxyanthranilic acid (8), and indole; the key step is a Mannich type cyclization accompanied with introduction of indole.