1411975-47-7

Basic information

• Product Name: tert-butyl 4-chloro-5-hydroxy-2-(4-phenoxybenzoyl)-1H-indole-1-carboxylate
• Synonyms: tert-butyl 4-chloro-5-hydroxy-2-(4-phenoxybenzoyl)-1H-indole-1-carboxylate
• CAS NO: 1411975-47-7
• Molecular Weight: 463.917
• Mol File: 1411975-47-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-chloro-5-hydroxy-2-(4-phenoxybenzoyl)-1H-indole-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-chloro-5-hydroxy-2-(4-phenoxybenzoyl)-1H-indole-1-carboxylate(1411975-47-7)
• EPA Substance Registry System: tert-butyl 4-chloro-5-hydroxy-2-(4-phenoxybenzoyl)-1H-indole-1-carboxylate(1411975-47-7)

Safety Data

• Hazardous Substances Data: 1411975-47-7(Hazardous Substances Data)

Upstream product

• 1207868-67-4 tert-butyl 5-hydroxy-2-(4-phenoxybenzoyl)-1H-indole-1-carboxylate 
• 1207869-51-9 (5-(tert-butyldimethylsilyloxy)-1H-indol-2-yl)(4-phenoxyphenyl)methanone 
• 67-36-7 4-phenoxy benzaldehyde 
• 1207869-50-8 C₂₇H₃₁NO₃Si 
• 106792-38-5 5-(tert-butyl-dimethyl-silanyloxy)-1H-indole 

Downstream Products

• 1207868-75-4 C₂₁H₁₄ClNO₃ 

Relevant articles and documents

Synthesis and structure based optimization of 2-(4-phenoxybenzoyl)-5- hydroxyindole as a novel CaMKII inhibitor

Based on 2-(4-phenoxybenzoyl)-5-hydroxyindole (2), a novel structural class of CaMKII inhibitors were synthesized and further optimized. The strong acidity of the hydroxyl group and the lipophilic group at the 4 and 6-positions were found to be necessary for strong CaMKII inhibition. Compound 25 was identified as a promising compound with 50-fold more potent inhibitory activity for CaMKII than 2. Compound 25 also showed high selectivity for CaMKII over off-target kinases.