141200-24-0

Basic information

• Product Name: darglitazone
• Synonyms: darglitazone
• CAS NO: 141200-24-0
• Molecular Formula: C₂₃H₂₀N₂O₄S
• Molecular Weight: 420.487
• Mol File: 141200-24-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.306g/cm³
• Refractive Index: 1.624
• CAS DataBase Reference: darglitazone(CAS DataBase Reference)
• NIST Chemistry Reference: darglitazone(141200-24-0)
• EPA Substance Registry System: darglitazone(141200-24-0)

Safety Data

• Hazardous Substances Data: 141200-24-0(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 141200-24-0 differently. You can refer to the following data:
1. Hypoglycemic (oral).
2. Darglitazone is a TZD (thiazolidinedione) that increases the sensiticirt od clls to insulin, stimulating insulin-induced P13K activity at submicromolar concentrations. It increases insulin effectiveness in diabetes mellitus subjects.

InChI:InChI=1/C23H20N2O4S/c1-14-18(24-22(29-14)17-5-3-2-4-6-17)11-12-19(26)16-9-7-15(8-10-16)13-20-21(27)25-23(28)30-20/h2-10,20H,11-13H2,1H3,(H,25,27,28)

Upstream product

• 125532-07-2 ethyl 2-<4-(diethoxymethyl)benzoyl>acetate 
• 125532-06-1 4-(diethoxymethyl)acetophenone 
• 125532-05-0 1-<4-(diethoxymethyl)phenyl>ethanol 
• 125531-53-5 4-[3-(5-Methyl-2-phenyl-4-oxazolyl)propionyl]benzaldehyde 
• 81172-89-6 terephthalaldehyde mono(diethylacetal) 
• 125531-47-7 5-<<4-<3-(5-methyl-2-phenyl-4-oxazolyl)propionyl>-phenyl>methylene>thiazolidine-2,4-dione 

Downstream Products

• 125532-03-8 5-<4-<3-(5-methyl-2-phemyl-4-oxazolyl)propyl>benzyl>-thiazolidine-2,4-dione 
• 141200-53-5 5-<4-<3-(5-methyl-2-phenyl-4-oxazolyl)-1-propenyl>-benzyl>thiazolidine-2,4-dione 
• 125549-29-3 5-{4-[1-[(Z)-Hydroxyimino]-3-(5-methyl-2-phenyl-oxazol-4-yl)-propyl]-benzyl}-thiazolidine-2,4-dione 
• 125531-74-0 5-<4-<3-(5-methyl-2-phenyl-4-oxazolyl)-1-hydroxypropyl>benzyl>thiazolidine-2,4-dione 
• 141200-79-5 5-{4-[1-[(Z)-Benzyloxyimino]-3-(5-methyl-2-phenyl-oxazol-4-yl)-propyl]-benzyl}-thiazolidine-2,4-dione 

Relevant articles and documents

ABC EXPRESSION PROMOTERS

The ABCA1 mRNA expression-promoting agent, LXRα mRNA expression-promoting agent, ABCG1 mRNA expression-promoting agent, cholesterol efflux-promoting agent, cholesteryl ester accumulation-inhibiting agent, ACAT-1 mRNA expression-inhibiting agent and CEH mRNA expression-promoting agent of the present invention are excellent in the ability to control cholesterol distribution in the body and have low toxicity.

METHOD OF INHIBITING ANGIOGENESIS

Angiogenesis is inhibited and the growth of tumors is treated by administering an effective amount of a PPAR gamma ligand/agonist, optionally with an RXR receptor ligand.

Use of thiazolidinedione derivatives in the treatment of polycystic ovary syndrome, gestational diabetes and disease states at risk for progressing to noninsulin-dependent diabetes mellitus

Novel methods of using thiazolidinone derivatives and related antihyperglycemic agents to treat populations at risk for developing noninsulin-dependent diabetes mellitus (NIDDM) and complications arising therefrom are disclosed. In one embodiment, the compounds of the invention are used to treat polycystic ovary syndrome in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus. In another embodiment, the compounds of the invention are used to treat gestational diabetes in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus.