141210-72-2Relevant academic research and scientific papers
Effect of a =X-NH-Fragment, (X = C, N), on Z/E Isomerization and ON/OFF Functionality of Isatin Arylhydrazones, ((Arylamino)Methylene)Indolin-2-Ones and Their Anions
?andrik, Róbert,Csicsai, Klaudia,Donovalová, Jana,Gáplovsky, Anton,Sokolík, Róbert,Tisovsky, Pavol
, (2020/07/25)
The subject of this work was the study of thermally and photochemically stimulated Z ? E isomerization and hydrazo ? azo tautomerism of Z- and E-isomers of isatin arylhydrazones and ((arylamino)methylene)indolin-2-ones and their anions. Using NMR, UV-Vis spectroscopy, kinetic measurements, and HPLC, we studied the relationship of structure, (Z- and E-isomers), of these compounds and hydrazo=azo tautomerism. The ON/OFF functionality of these compounds and their anions using light to stimulate switching between ON and OFF states was investigated. We pointed out the characterization of the effect of =N- and =CH- structural fragments and aryl structure on ON and OFF states of isatin arylhydrazones and ((arylamino)methylene)indolin-2-ones.
Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials
Praveen Kumar,Gut, Jiri,Guedes, Rita C.,Rosenthal, Philip J.,Santos, Maria M.M.,Moreira, Rui
experimental part, p. 927 - 933 (2011/04/16)
The design, synthesis and evaluation of 3-methylene-substituted indolinones as falcipain inhibitors and antiplasmodial agents are described. These compounds react readily with thiols via an addition-elimination mechanism, indicating their potential as cys
LACTAM AND AMIDE ACETALS. 69. SYNTHESIS AND PROPERTIES OF 3-(AMINOMETHYLENE)-2-INDOLINONE DERIVATIVES
Golovko, T. V.,Solov'eva, N. P.,Bogdanova, G. A.,Sheinker, Yu. N.,Granik, V. G.
, p. 952 - 959 (2007/10/02)
Oxindole derivatives reacted with the diethyl acetals of dimethylformamide and dimethylacetamide to give the corresponding derivatives of 3-(aminomethylene)-, (aminoethylidene)-, and (ethoxyethylidene)-2-indolinone.These products were then easily converted to N-aryl- and N-alkylaminomethyleneoxindoles upon treatment with aryl or alkyl amines.The alkylation of N,N-dimethylaminomethylene-2-indolinones by dimethyl sulfate and triethyloxonium tetrafluoroborate, and the reactions of the resulting methyl sulfates and tetrafluoroborates with nucleophilic reagents were studied.The configuration of the 3-(aminomethylene)-2-indolinone derivatives prepared at the enamine C=C double bond was investigated by NMR.The free energies of activation for the cis-trans isomerization were determined in a number of cases.
ACETALS OF LACTAMS AND ACID AMIDES. 67. POLAROGRAPHIC BEHAVIOR OF ENAMINES OF THE INDOLES SERIES IN ANHYDROUS DMF
Polievktov, M. K.,Petrishcheva, O. A.,Ryabova, S. Yu.,Golovko, T. V.,Granik, V. G.
, p. 511 - 516 (2007/10/02)
The polarographic behavior of derivatives of 2-aminomethyleneindoxyl and 3-aminomethyleneoxindole in anhydrous DMF has been studied and the results compared with data on the polarographic reduction of substituted aminomethyleneacetophenones and of related
β,β-Diacyl-enamines and -enoles, 6: An Efficient Synthesis of Aminoalkylidene Derivatives Fivemembered Active Methylene Compounds
Wolfbeis, Otto S.
, p. 369 - 384 (2007/10/02)
Trimethyl orthoacetate, orthopropionate or orthobenzoate in contrast to orthoformiate do not undergo a three component condensation with anilines and cyclic sixmembered active methylene compounds to the corresponding N-substituted aminomethylene derivativ
