141214-27-9

Basic information

• Product Name: Proline, 2-methyl-5-oxo-1-phenyl-4-(phenylamino)-, methyl ester
• CAS NO: 141214-27-9
• Molecular Formula: C19H20N2O3
• Molecular Weight: 324.379
• Mol File: 141214-27-9.mol

Chemical Properties

• CAS DataBase Reference: Proline, 2-methyl-5-oxo-1-phenyl-4-(phenylamino)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Proline, 2-methyl-5-oxo-1-phenyl-4-(phenylamino)-, methyl ester(141214-27-9)
• EPA Substance Registry System: Proline, 2-methyl-5-oxo-1-phenyl-4-(phenylamino)-, methyl ester(141214-27-9)

Safety Data

• Hazardous Substances Data: 141214-27-9(Hazardous Substances Data)

Upstream product

• 26458-36-6 methyl 2-methyl-5-oxo-1-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2-carboxylate 

Downstream Products

• 141214-38-2 3-anilino-5-hydroxymethyl-5-methyl-1-phenyl pyrrolidin-2-one 

Relevant articles and documents

The influence of α-amido/thioamido functionality in ester reduction with sodium borohydride

Sodium borohydride in methanol smoothly reduces the esters of α-amino acids having N-acyl (orthioacyl)-N-alkyl (-NRCOR′ or -NRCSR′) substituents, producing amino alcohol derivatives. Esters with α-NHCOR or-CONRR′ functionality however remain unaffected. Electron-withdrawing property of the substituent appears to play a crucial role, anion formation with -NHCOR group perhaps diminishing its effect.

A convenient reduction of substituted amino-acid esters

Esters having N-alkyl-N-acyl (orthioacyl) functionality at the α-position are smoothly reduced with NaBH4-MeOH at 0-5°C in very good yields.