141214-36-0

Basic information

• Product Name: 1,4-Dioxa-7-azaspiro[4.4]nonane-6-thione, 8-(hydroxymethyl)-8-methyl-7-phenyl-
• CAS NO: 141214-36-0
• Molecular Formula: C14H17NO3S
• Molecular Weight: 279.36
• Mol File: 141214-36-0.mol

Chemical Properties

• CAS DataBase Reference: 1,4-Dioxa-7-azaspiro[4.4]nonane-6-thione, 8-(hydroxymethyl)-8-methyl-7-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dioxa-7-azaspiro[4.4]nonane-6-thione, 8-(hydroxymethyl)-8-methyl-7-phenyl-(141214-36-0)
• EPA Substance Registry System: 1,4-Dioxa-7-azaspiro[4.4]nonane-6-thione, 8-(hydroxymethyl)-8-methyl-7-phenyl-(141214-36-0)

Safety Data

• Hazardous Substances Data: 141214-36-0(Hazardous Substances Data)

Upstream product

• 141214-25-7 methyl 3,3-(ethylenedioxy)-5-methyl-2-oxo-1-phenylpyrrolidine-5-carboxylate 
• 26458-36-6 methyl 2-methyl-5-oxo-1-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2-carboxylate 
• 26458-37-7 methyl 2,3-dioxo-5-methyl-1-phenyl pyrrolidine-5-carboxylate 
• 141214-26-8 methyl 3,3-(ethylenedioxy)-5-methyl-1-phenyl-2-thiopyrrolidine-5-carboxylate 

Relevant articles and documents

The influence of α-amido/thioamido functionality in ester reduction with sodium borohydride

Sodium borohydride in methanol smoothly reduces the esters of α-amino acids having N-acyl (orthioacyl)-N-alkyl (-NRCOR′ or -NRCSR′) substituents, producing amino alcohol derivatives. Esters with α-NHCOR or-CONRR′ functionality however remain unaffected. Electron-withdrawing property of the substituent appears to play a crucial role, anion formation with -NHCOR group perhaps diminishing its effect.

A convenient reduction of substituted amino-acid esters

Esters having N-alkyl-N-acyl (orthioacyl) functionality at the α-position are smoothly reduced with NaBH4-MeOH at 0-5°C in very good yields.