1412427-37-2

Basic information

• Product Name: isopropyl 3-(2-(((((3aR,4R,6R,6aR)-6-(2-amino-6-chIoro-9H-purin-9-yI)-6a-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxoI-4-yI)methoxy)(((S)-1-isopropoxy-1-oxopropan-2-yI)amino)phosphoryl)oxy)phenyl)propanoate
• Synonyms: isopropyl 3-(2-(((((3aR,4R,6R,6aR)-6-(2-amino-6-chIoro-9H-purin-9-yI)-6a-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxoI-4-yI)methoxy)(((S)-1-isopropoxy-1-oxopropan-2-yI)amino)phosphoryl)oxy)phenyl)propanoate
• CAS NO: 1412427-37-2
• Molecular Weight: 725.092
• Mol File: 1412427-37-2.mol

Chemical Properties

• CAS DataBase Reference: isopropyl 3-(2-(((((3aR,4R,6R,6aR)-6-(2-amino-6-chIoro-9H-purin-9-yI)-6a-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxoI-4-yI)methoxy)(((S)-1-isopropoxy-1-oxopropan-2-yI)amino)phosphoryl)oxy)phenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: isopropyl 3-(2-(((((3aR,4R,6R,6aR)-6-(2-amino-6-chIoro-9H-purin-9-yI)-6a-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxoI-4-yI)methoxy)(((S)-1-isopropoxy-1-oxopropan-2-yI)amino)phosphoryl)oxy)phenyl)propanoate(1412427-37-2)
• EPA Substance Registry System: isopropyl 3-(2-(((((3aR,4R,6R,6aR)-6-(2-amino-6-chIoro-9H-purin-9-yI)-6a-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxoI-4-yI)methoxy)(((S)-1-isopropoxy-1-oxopropan-2-yI)amino)phosphoryl)oxy)phenyl)propanoate(1412427-37-2)

Safety Data

• Hazardous Substances Data: 1412427-37-2(Hazardous Substances Data)

Upstream product

• 640725-74-2 (2R,3R,4R,5R)-2-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol 
• 1412427-31-6 C₁₈H₂₇ClNO₆P 
• 1412427-36-1 (3aR,4R,6R,6aR)-4-(2-amino-6-chIoro-9H-purin-9-yI)-6-(hydroxymethyl)-3a-methyltetrahydroturo[3,4-d] [1,3]dioxol-2-one 
• 1412427-35-0 (2R,3R,4R,5R)-2-(2-amino-6-chIoro-9H-purin-9-yI)-5-(((tertbutyldimethylsilyl)oxy)methyl)-3-methyltetrahydrofuran-3,4-diol 

Downstream Products

• 1412427-38-3 isopropyl 3-(2-(((((3aR,4R,6R,6aR)-6-(2,6-diamino-9H-purin-9-yI)-6a-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxoI-4-yI)methoxy)(((S)-1-isopropoxy-1-oxopropan-2-yI)amino)phosphoryl)oxy)phenyl)propanoate 
• 1412427-39-4 isopropyl 3-(2-(((((3aR,4R,6R,6aR)-6-(2,6-diamino-9H-purin-9-yI)-6a-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxoI-4-yI)methoxy)(((S)-1-isopropoxy-1-oxopropan-2-yI)amino)phosphoryl)oxy)phenyl)propanoate 

Relevant articles and documents

PURINE MONOPHOSPHATE PRODRUGS FOR TREATMENT OF VIRAL INFECTIONS

The present invention is directed to compounds, compositions and methods for treating or preventing viral infections using nucleoside analog monophosphate prodrugs. More specifically, HCV, Norovirus, Saporovirus, Dengue virus, Chikungunya virus and Yellow fever in human patients or other animal hosts. The compounds are certain 2,6-diamino 2-C-methyl purine nucleoside monophosphate prodrugs and modified prodrug analogs, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HCV, Norovirus, Saporovirus, Dengue virus, Chikungunya virus and Yellow fever. This invention teaches how to modify the metabolic pathway of 2,6-diamino 2'-C-methyl purine and deliver nucleotide triphosphate(s) to polymerases at heretofore unobtainable therapeutically-relevant concentrations.