1412439-75-8

Upstream product

• 1412439-71-4 2’,5’-dideoxy-2’,2’-difluoro-4’,5’-methylene-1’-O-(2-nitrobenzyl)-α-D-ribofuranose 
• 1412439-70-3 2’,5’-dideoxy-3’-O-acetyl-2’,2’-difluoro-4’,5’-methylene-1’-O-(2-nitrobenzyl)-α-Dribofuranose 
• 1412439-69-0 2’,5’-dideoxy-3’-O-acetyl-2’,2’-difluoro-5’-iodo-1’-O-(2-nitrobenzyl)-α-D-ribofuranose 
• 1412439-68-9 2’,5’-dideoxy-2’,2’-difluoro-5’-iodo-1’-O-(2-nitrobenzyl)-α-D-ribofuranose 
• 1412439-67-8 2’-deoxy-1’-O-(2-nitrobenzyl)-2’,2’-difluoro-α-D-ribofuranose 
• 1412439-65-6 2’-deoxy-2’,2’-difluoro-4’-methoxy-1’-O-(2-nitrobenzyl)-α-L-lyxofuranose 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 1412439-66-7 2’-deoxy-2’,2’-difluoro-1’-O-(2-nitrobenzyl)-3’,5’-O-benzoyl-α-D-ribofuranose 

Downstream Products

• 1412439-72-5 2’-deoxy-2’,2’-difluoro-5’-O-(4,4’-dimethoxy-trityl)-4’-methoxy-1’-O-(2-nitrobenzyl)-α-L-lyxofuranose cyanoethyl N,N-diisopropylphosphoramidite 

Relevant academic research and scientific papers

Difluoro-C4′-oxidized abasic site for efficient amine modification in biological systems

An oligodeoxynucleotide (ODN) containing a 2′,2′-difluorinated analogue of a C4′-oxidized abasic site (C4′-OAS) was designed for the amine modification of biomolecules that interact with nucleic acids. In contrast to the parent C4′-OAS, which yielded amine-modified products accompanied by DNA strand scission, the ODN containing the difluoro C4′-OAS efficiently yielded products carrying ODNs. The amine modification proceeded without additional reagents being required and might be applicable to reactions in biological systems.