1412451-01-4Relevant academic research and scientific papers
Identification of a novel and orally available benzimidazole derivative as an NPY Y5 receptor antagonist with in vivo efficacy
Tamura, Yuusuke,Omori, Naoki,Kouyama, Naoki,Nishiura, Yuji,Hayashi, Kyouhei,Watanabe, Kana,Yukioka, Hideo,Sato, Hiroki,Okuno, Takayuki,Tanaka, Yukari,Chiba, Takeshi
, p. 6554 - 6558,5 (2012)
Optimization of lead compound 2 is described, mainly focusing on modification at the C-2 position of the benzimidazole core. Replacement of the phenyl linker of 2 with saturated rings resulted in identification of compound 8b which combines high Y5 recept
