1412499-23-0

Basic information

• Product Name: {5-(2-tert-butoxycarbonylamino-propionylamino)-1-[4-(2,3,5,6-tetrafluoro-pyridin-4-ylethynyl)-phenylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester
• Synonyms: {5-(2-tert-butoxycarbonylamino-propionylamino)-1-[4-(2,3,5,6-tetrafluoro-pyridin-4-ylethynyl)-phenylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester
• CAS NO: 1412499-23-0
• Molecular Weight: 665.685
• Mol File: 1412499-23-0.mol

Chemical Properties

• CAS DataBase Reference: {5-(2-tert-butoxycarbonylamino-propionylamino)-1-[4-(2,3,5,6-tetrafluoro-pyridin-4-ylethynyl)-phenylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {5-(2-tert-butoxycarbonylamino-propionylamino)-1-[4-(2,3,5,6-tetrafluoro-pyridin-4-ylethynyl)-phenylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester(1412499-23-0)
• EPA Substance Registry System: {5-(2-tert-butoxycarbonylamino-propionylamino)-1-[4-(2,3,5,6-tetrafluoro-pyridin-4-ylethynyl)-phenylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester(1412499-23-0)

Safety Data

• Hazardous Substances Data: 1412499-23-0(Hazardous Substances Data)

Upstream product

• 15761-38-3 L-N-Boc-Ala 
• 1185249-12-0 4-(2,3,5,6-tetrafluoropyridin-4-ylethynyl)aniline 
• 55757-60-3 N-α-(tert-butoxycarbonyl)-L-lysine methyl ester 

Relevant articles and documents

Optimizing Protonation States for Selective Double-Strand DNA Photocleavage in Hypoxic Tumors: PH-Gated Transitions of Lysine Dipeptides

We report pH-switching properties of the new family of dipeptide-acetylene conjugates where pH-gated light-activated double-strand (ds) DNA cleavage is controlled by variations in electronic and geometric parameters. The conjugates have higher activities at the slightly acidic pH values that separate normal and cancerous tissue (pH a neutral molecule to a dication results in dramatically increased efficiency of ds DNA photocleavage, the most therapeutically valuable type of DNA cleavage.

DIPEPTIDE ACETYLENE CONJUGATES AND A METHOD FOR PHOTOCLEAVAGE OF DOUBLE STRAND DNA BY DIPEPTIDE ACETYLENE CONJUGATES

Photoreactive DNA cleaving conjugate compounds are provided comprising a DNA cleaving moiety which comprises an aryl alkyne group and a polyfunctional pH-regulated DNA-binding moiety which comprises at least one or two amino groups.