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1412499-28-5

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1412499-28-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1412499-28-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,1,2,4,9 and 9 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1412499-28:
(9*1)+(8*4)+(7*1)+(6*2)+(5*4)+(4*9)+(3*9)+(2*2)+(1*8)=155
155 % 10 = 5
So 1412499-28-5 is a valid CAS Registry Number.

1412499-28-5Relevant articles and documents

Opening enediyne scissors wider: pH-dependent DNA photocleavage by meta-diyne lysine conjugates

Kaya, Kemal,Johnson, Madeleine,Alabugin, Igor V.

, p. 748 - 758 (2015)

Abstract Photochemical activation of meta-diynes incapable of Bergman and C1-C5 cyclizations still leads to efficient double-strand DNA cleavage. Spatial proximity of the two arylethynyl groups is not required for efficient DNA photocleavage by the enediyne-lysine conjugates. Efficiency of the cleavage is a function of the external pH and DNA damage is strongly enhanced at pH 7. The pH-dependence of the DNA photocleavage activity stems from the protonation states of lysine amino groups, the internal electron donors responsible for intramolecular PET quenching and deactivation of the photoreactive excited states. DNA-binding analysis suggests intercalative DNA binding for phenyl substituted conjugate and groove binding for TFP-substituted conjugate. Additional insights in the possible mechanism for DNA damage from the ROS (Reactive Oxygen Species) scavenger experiments found that generation of singlet oxygen is partially involved in the DNA damage. Upon photochemical activation, meta-bis-tetrafluoropyridinylalkyne-lysine conjugates induce pH-dependent DNA ds-photocleavage. Efficiency of DNA damage is strongly enhanced at pH 7. The observed pH-dependence of the DNA photocleavage activity stems from change in the protonation states of lysine amino groups. The ROS (Reactive Oxygen Species) scavenger experiments suggest that singlet oxygen is partially involved in the DNA damage.

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