141256-04-4 Usage
General Description
QS-21 is a saponin compound derived from the bark of the Quillaja saponaria tree. It is a potent adjuvant, meaning it can enhance the body's immune response to vaccines and other immunotherapies. QS-21 has been studied for its ability to stimulate both the innate and adaptive immune systems, making it a valuable component in the development of new vaccines and cancer treatments. However, it can also cause severe local reactions at the site of injection, and efforts are ongoing to find ways to reduce its toxicity while maintaining its adjuvant properties. QS-21 shows promising potential for improving the efficacy of vaccines and immunotherapies, but further research is needed to fully understand its mechanisms and to optimize its use in clinical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 141256-04-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,2,5 and 6 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 141256-04:
(8*1)+(7*4)+(6*1)+(5*2)+(4*5)+(3*6)+(2*0)+(1*4)=94
94 % 10 = 4
So 141256-04-4 is a valid CAS Registry Number.
InChI:InChI=1/C92H148O46/c1-13-36(3)45(126-54(101)25-41(98)24-46(37(4)14-2)127-80-64(111)58(105)48(30-94)128-80)23-40(97)26-55(102)132-70-39(6)125-82(73(67(70)114)136-79-66(113)61(108)69(38(5)124-79)133-78-63(110)59(106)49(32-122-78)130-84-75(116)91(120,34-96)35-123-84)138-85(119)92-22-21-86(7,8)27-43(92)42-15-16-51-87(9)19-18-53(88(10,33-95)50(87)17-20-89(51,11)90(42,12)28-52(92)100)131-83-74(137-81-65(112)60(107)57(104)47(29-93)129-81)71(68(115)72(135-83)76(117)118)134-77-62(109)56(103)44(99)31-121-77/h15,33,36-41,43-53,56-75,77-84,93-94,96-100,103-116,120H,13-14,16-32,34-35H2,1-12H3,(H,117,118)/t36?,37?,38-,39+,40?,41?,43-,44+,45?,46?,47+,48-,49+,50+,51+,52+,53-,56-,57-,58-,59-,60-,61-,62+,63+,64+,65+,66+,67-,68-,69-,70-,71-,72-,73+,74+,75-,77-,78-,79-,80+,81+,82-,83+,84-,87-,88-,89+,90+,91+,92+/m0/s1
141256-04-4Relevant articles and documents
TRITERPENE SAPONIN SYNTHESIS, INTERMEDIATES AND ADJUVANT COMBINATIONS
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Page/Page column 104; 125, (2018/11/10)
The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.
