141261-62-3Relevant articles and documents
Sequence Dependence in Solid-Phase-Synthesis-Cyclization-Cleavage for Cyclo(-arginyl-glycyl-aspartyl-phenylglycyl-)
Nishino, Norikazu,Xu, Ming,Mihara, Hisakazu,Fujimoto, Tsutomu,Ueno, Yukio,Kumagai, Hiromichi
, p. 1479 - 1482 (2007/10/02)
A cyclic tetrapeptide with inhibitory activity toward cell adhesion, cyclo(-Arg-Gly-Asp-Phe-) (phg, phenylglycine) (IC50 = 10 μM), was synthesized.The cyclization-cleavage of the protected precursor from the oxime resin significantly depended on the sequences of the linear tetrapeptides assembled by solid-phase-synthesis on the resin. Key words: peptide synthesis; oxime resin; solid-phase-synthesis and cyclization-cleavage; cyclic tetrapeptide; Arg-Gly-Asp sequence.