141263-06-1Relevant academic research and scientific papers
Direct glycosylation of unprotected and unactivated sugars using bismuth nitrate pentahydrate
Polanki, Innaiah K.,Kurma, Siva H.,Bhattacharya, Asish K.
, p. 196 - 205 (2015/06/08)
Bi(NO3)3, a low-cost, mild, and environmentally green catalyst, has been successfully utilized for Fischer glycosylation for the synthesis of alkyl/aryl glycopyranosides by reacting unprotected sugars, namely, D-glucose, L-rhamnose, D-galactose, D-arabinose, and N-acetyl-D-glucosamine with various alcohols in good to excellent yields. The glycosides were formed with high α-selectivity. Further, an expedient separation of α- and β-glycosides using silver nitrate-impregnated silica gel flash liquid chromatography has been developed.
HYDROLASE ENZYME SUBSTRATES AND USES THEREOF
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Page/Page column 63, (2012/08/07)
The present invention provides novel methods for determining the presence or amount of a hydrolytic enzyme in a sample, based on novel substrates for the enzymes, and also provides compositions and methods that provide highly sensitive assay methods for such hydrolytic enzymes.
Synthesis, biological activity of salidroside and its analogues
Guo, Yibing,Zhao, Yahong,Zheng, Cheng,Meng, Ying,Yang, Yumin
experimental part, p. 1627 - 1629 (2011/02/24)
Salidroside is a phenylpropanoid glycoside isolated from Rhodiola rosea L., a traditional Chinese medicinal plant, and has displayed a broad spectrum of pharmacological properties. In this paper, about 18 novel salidroside analogues were prepared through Koenigs-Knorr method, the effects of these compounds over PC12 was assessed with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The novel compounds differ in the substituents attached to the benzene ring or in the glycosyl donor. According to the data, compounds (3,5-dimethoxyphenyl)methyl β-D-glucopyranoside and (3,5-dimethoxyphenyl) methyl β-D-galactopyranoside with methoxy group at 3 and 5-positions of the benzene ring were the most viability at concentration of 300 μmol/l and 60 μmol/l, respectively.
Convenient syntheses of 2,3,4,6-tetra-O-alkylated D-glucose and D-galactose
Kaesbeck, Ludwig,Kessler, Horst
, p. 169 - 173 (2007/10/03)
Convenient syntheses of the 2,3,4,6-tetra-O-benzylated and -allylated D-glucopyranoses 1 and 2 and the corresponding D-galactopyranoses 3 and 4 are described. The D-glucose derivatives 1 and 2 were obtained from inexpensive sucrose by peralkylation and subsequent acid hydrolysis. In this reaction sequence an alkylated D-fructofuranosyl cation is generated which was trapped by different nucleophiles to afford 4-benzyloxymethylenefurfural (8) and the alkylated D-fructosides 7, 8 and 10. On the other hand 2,3,4,6-tetra-O-benzyl-D-galactose 3 was synthesized by oxidative cleavage of ethyl 2,3,4,6-tetra-O-benzyl-1-thio-α,β-D-galactopyranoside (11) with aqueous N-bromosuccinimide. The alternative route for the preparation of 2,3,4,6-tetra-O-allyl-D-glucopyranoside (2) via p-methoxybenzyl β-D-glucoside is less attractive. However, this route was used for the synthesis of 2,3,4,6-tetra-O-allyl-D-galactose (4). VCH Verlagsgesellschaft mbH, 1997.
Regioselective sulfation of galactose derivatives through the stannylene procedure. New synthesis of the 3'-O-Sulfated Lewisa trisaccharide
Lubineau,Lemoine
, p. 8795 - 8796 (2007/10/02)
Free or 6-protected β-D-galactopyranosides afforded, in excellent yields, the 3'-O-sulfate as the only product through the stannylene procedure. This methodology was successfully applied to the synthesis of the 3'-O- sulfated Lewisa trisacchari
Synthesis of trisaccharide methyl glycosides related to fragments of the capsular polysaccharide of Streptococcus pneumoniae type 18C
Van Steijn,Kamerling,Vliegenthart
, p. 229 - 245 (2007/10/02)
The synthesis is reported of methyl 3-0-(4-0-β-D-galactopyranosyl-α-D-glucopyranosyl)-α-L- rhamnopyranoside (1), methyl 2-0-α-D-glucopyranosyl-4-0-β-D-glucopyranosyl-β-D- galactopyranoside (3), methyl 3-0-(4-0-β-D-galactopyranosyl-α-D-glucopyranosyl)-α-L-
