141277-85-2

Upstream product

• 141277-82-9 ethyl (E)-2-[(2R,5R)-2-methyl-5-(prop-1-en-2-yl)cyclohexylidene]acetate 
• 141277-83-0 [(2R,5R)-5-Hydroxy-2-methyl-cyclohex-(E)-ylidene]-acetic acid ethyl ester 
• 5524-05-0 (2R,5R)-5-isopropenyl-2-methylcyclohexanone 
• 142980-89-0 ethyl <(2'R,5'R)-1',5-'dihydroxy-2'-methylcyclohexyl>ethanoate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 141277-84-1 (2E)-ethyl <(2'R,5'R)-5'-<(tert-butyldimethylsilyl)oxy>-2'-methylcyclohexylidene>ethanoate 
• 142980-90-3 ethyl <(2'R,5'R)-5'-<(tert-butyldimethylsilyl)oxy>-1'-hydroxy-2'-methylcyclohexyl>ethanoate 
• 142980-88-9 ethyl <(2'R,5'R)-5'-acetoxy-1'-hydroxy-2'-methylcyclohexyl>ethanoate 
• 142980-87-8 ethyl <(2'R,5'R)-6-hydroperoxy-2',6-'dimethylbicyclo<3.2.1>-7'-oxaoctyl>ethanoate 

Downstream Products

• 141277-80-7 (2E)-<2-<(2'R,5'R)-5'-<(tert-butyldimethylsilyl)oxy>-2'-methylcyclohexylidene>ethyl>diphenylphosphine oxide 
• 141277-87-4 25-<(methoxymethyl)oxy>-10(R),19-dihydro-(5E)-3-epivitamin D₂ tert-butyldimethylsilyl ether 
• 142980-94-7 10(R),19-dihydro-(5E)-3-epivitamin D₂ tert-butyldimethylsilyl ether 
• 143060-74-6 25-hydroxy-10(R),19-dihydro-(5E)-3-epivitamin D₂ 
• 143060-73-5 10(R),19-dihydro-(5E)-3-epivitamin D₂ 
• 141277-86-3 tert-Butyl-{(1R,4R)-3-[2-chloro-eth-(E)-ylidene]-4-methyl-cyclohexyloxy}-dimethyl-silane 

Relevant academic research and scientific papers

A Synthesis of A-Ring Synthons for Dihydrotachysterols

Phosphine oxides 1 and 2, enantiomeric synthons for the preparation of dihydrotachysterols, were synthesized from the appropriate dihydrocarvones

A Convergent Approach to the Dihydrotachysterol Diene System. Application to the Synthesis of Dihydrotachysterol2 (DHT2), 25-Hydroxydihydrotachysterol2 (25-OH-DHT2), 10(R),19-dihydro-(5E)-3-epivitamin D2, and 25-Hydroxy-10(R),19-dihydro-(5E)-3-epivitamin D2

Total synthesis of A-ring fragments of 10(S),19-dihydrovitamins D and 10(R),19-dihydro-(5E)-epivitamins D from (+)-(S)-carvone and (-)-(R)-carvone is described.These fragments were used for convergent synthesis of dihydrotachysterol2 (DHT2), 25-hydroxydihydrotachysterol2, 10(R),19-dihydro-(5E)-3-epivitamin D2, and 25-hydroxy-10(R),19-dihydro-(5E)-3-epivitamin D2.