141287-70-9Relevant academic research and scientific papers
Synthesis and preliminary structure-activity relationships of 1-[(3-fluoro-4-pyridinyl)amino]-3-methyl-1H-indol-5-yl methyl carbamate (P10358), a novel acetylcholinesterase inhibitor
Martin, Lawrence L.,Davis, Larry,Klein, Joseph T.,Nemoto, Peter,Olsen, Gordon E.,Bores, Gina M.,Camacho, Fernando,Petko, Wayne W.,Rush, Douglas K.,Selk, David,Smith, Craig P.,Vargas, Hugo M.,Winslow, James T.,Effland, Richard C.,Fink, David M.
, p. 157 - 162 (1997)
A series of carbamate analogs of besipirdine (HP 749) was synthesized as potential agents with enhanced cholinomimetic properties for the treatment of Alzheimer's disease. Compound 5a (P10358, 1-[(3-fluoro-4-pyridinyl)amino]-3-methyl-1H-indol-5-yl methyl carbamate) emerged as a potent, reversible acetylcholinesterase inhibitor that significantly enhanced performance on oral or parenteral administration in learning and memory paradigms.
