1412898-94-2Relevant academic research and scientific papers
Highly regio-, diastereo-, and enantioselective 1,6- and 1,8-additions of azlactones to Di- and trienyl N -acylpyrroles
Uraguchi, Daisuke,Yoshioka, Ken,Ueki, Yusuke,Ooi, Takashi
, p. 19370 - 19373 (2012)
A vinylog of Michael addition (1,6-addition) of azlactones to η-substituted dienyl N-acylpyrroles has been developed with virtually complete 1,6-, diastereo-, and enantioselectivities by means of chiral P-spiro triaminoiminophosphorane as a catalyst. This system has been successfully extended to an unprecedented bis-vinylog of Michael addition (1,8-addition) of azlactones to ζ-substituted trienyl N-acylpyrroles with high levels of regio- and stereocontrol.
