1412903-10-6

Basic information

• Product Name: C₂₂H₂₆N₂O
• Synonyms: C₂₂H₂₆N₂O
• CAS NO: 1412903-10-6
• Molecular Weight: 334.461
• Mol File: 1412903-10-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₆N₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₆N₂O(1412903-10-6)
• EPA Substance Registry System: C₂₂H₂₆N₂O(1412903-10-6)

Safety Data

• Hazardous Substances Data: 1412903-10-6(Hazardous Substances Data)

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 39186-58-8 4-bromo-2,2-diphenylbutyronitrile 
• 1412903-08-2 4-(4-hydroxy-1-piperidyl)-2,2-diphenylbutanenitrile 
• 74-88-4 methyl iodide 

Relevant articles and documents

Structure-activity relationship exploration of Kv1.3 blockers based on diphenoxylate

Diphenoxylate, a well-known opioid agonist and anti-diarrhoeal agent, was recently found to block Kv1.3 potassium channels, which have been proposed as potential therapeutic targets for a range of autoimmune diseases. The molecular basis for this Kv1.3 blockade was assessed by the selective removal of functional groups from the structure of diphenoxylate as well as a number of other structural variations. Removal of the nitrile functional group and replacement of the C-4 piperidinyl substituents resulted in several compounds with submicromolar IC50 values.