1412908-45-2Relevant academic research and scientific papers
Highly stereoselective modifications of peptides via Pd-catalyzed allylic alkylation of internal peptide amide enolates
Datta, Swarup,Bayer, Anton,Kazmaier, Uli
supporting information, p. 8268 - 8275,8 (2012/12/12)
Pd-catalyzed allylations are excellent tools for stereoselective peptide modifications, showing several advantages compared to normal alkylations. Reactions of internal peptide amide enolates with Pd-allyl complexes proceed not only with high yields of up to 86%, they show also high regio- and diastereoselectivities (88-99%), giving rise to the trans-configured products. Therefore, this protocol is a powerful synthetic tool for the synthesis of natural product and drug molecules.
Highly stereoselective modifications of peptides via Pd-catalyzed allylic alkylation of internal peptide amide enolates
Datta, Swarup,Bayer, Anton,Kazmaier, Uli
supporting information, p. 8268 - 8275 (2013/01/15)
Pd-catalyzed allylations are excellent tools for stereoselective peptide modifications, showing several advantages compared to normal alkylations. Reactions of internal peptide amide enolates with Pd-allyl complexes proceed not only with high yields of up to 86%, they show also high regio- and diastereoselectivities (88-99%), giving rise to the trans-configured products. Therefore, this protocol is a powerful synthetic tool for the synthesis of natural product and drug molecules. The Royal Society of Chemistry 2012.
