1412939-06-0

Basic information

• Product Name: C₁₃H₁₆O₃
• Synonyms: C₁₃H₁₆O₃
• CAS NO: 1412939-06-0
• Molecular Weight: 220.268
• Mol File: 1412939-06-0.mol

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₆O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₆O₃(1412939-06-0)
• EPA Substance Registry System: C₁₃H₁₆O₃(1412939-06-0)

Safety Data

• Hazardous Substances Data: 1412939-06-0(Hazardous Substances Data)

Upstream product

• 121-33-5 vanillin 
• 39953-41-8 3-methoxy-4-[(3-methylbut-2-en-1-yl)oxy] benzaldehyde 

Downstream Products

• 1412939-10-6 (E)-3-[5-(1,2-dimethyl-2-propenyl)-4-hydroxy-3-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one 
• 1412939-08-2 (E)-3-[5-(1,2-dimethyl-2-propenyl)-4-hydroxy-3-methoxyphenyl]-1-(2,4-dihydroxyphenyl)-2-propen-1-one 
• 1412939-09-3 (E)-3-[5-(1,2-dimethyl-2-propenyl)-4-hydroxy-3-methoxyphenyl]-1-(2,4,6-trihydroxyphenyl)-2-propen-1-one 
• 1412939-07-1 C₁₅H₂₀O₄ 

Relevant articles and documents

Synthesis of licochalcones and inhibition effects on radical-induced oxidation of DNA

This study deals with the influence of phenolic hydroxyl groups on the antioxidant capacities of licochalcones. (E)-3-[5-(1,2-Dimethyl-2-propenyl)-4- hydroxy-3-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one (HMP), (E)-3-[5-(1,2-dimethyl-2-propenyl)-4-hydroxy-3-methoxyphenyl]-1-(2, 4-dihydroxyphenyl)-2-propen-1-one (DHM), and (E)-3-[5-(1,2-dimethyl-2-propenyl)- 4-hydroxy-3-methoxyphenyl]-1-(2,4,6-trihydroxyphenyl)-2-propen-1-one (HMT) were synthesized via abnormal Claisen rearrangement and Claisen-Schmidt condensation. The antioxidant capacities were evaluated in hydroxyl radical ( ?OH)-, Cu2+/glutathione (GSH)-, and 2,2′-azobis(2-amidinopropane hydrochloride) (AAPH)-induced oxidation of DNA. It was found that only HMP possessed weak ability to inhibit ?OH-induced oxidation of DNA, and DHM and HMT cannot protect DNA against the oxidation. All the licochalcones employed herein can retard Cu 2+/GSH-induced oxidation of DNA, the activity followed the order of HMP > DHM > HMT. Hence, more hydroxyl groups did not ameliorate the antioxidant effectiveness in the aforementioned experimental systems. On the other hand, HMT, DHM, and HMP can scavenge 5.61, 2.42, and 1.68 radicals, respectively, when they were applied to protect DNA against AAPH-induced oxidation. This result demonstrated that more hydroxyl groups enhanced the antioxidant capacities of licochalcones in this case. The obtained information was beneficial for designing novel licochalcones.