1412945-45-9

Upstream product

• 1412945-42-6 C₈H₁₁N₆O₂^(1-)*Na⁽¹⁺⁾ 
• 101156-40-5 (6R,7R)-4-methoxybenzyl-3-(iodomethyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 104146-10-3 (6R,7R)-3-Chloromethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 

Downstream Products

• 1412945-50-6 C₂₄H₂₆N₈O₆S 
• 1413936-09-0 C₂₄H₂₅N₈O₆S^(1-)*K⁽¹⁺⁾ 

Relevant academic research and scientific papers

Synthesis of cephalosporin-3′-diazeniumdiolates: Biofilm dispersing NO-donor prodrugs activated by β-lactamase

Use of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin

REGULATION OF NITRIC OXIDE RELEASE AND BIOFILM DEVELOPMENT

Regulation of nitric oxide release and biofilm development Abstract The present invention relates generally to methods and compounds for regulating the release of nitric oxide in the vicinity of biofilm-forming microorganisms to regulate programmed cell death in the microorganisms and thereby promote dispersal of microorganism from biofilms and/or inhibit biofilm formation or development. More particularly, the invention relates to the use of compounds to provide spatial and temporal control over nitric oxide release.