141306-09-4

Usage

Derivative of indole

Heterocyclic compound 1H-Indole, 3-(4-fluorophenyl)-5-methyl- is derived from the heterocyclic compound indole, which is a structure containing a benzene ring fused to a pyrrole ring.

Fluorophenyl group

Attached to the third carbon atom A phenyl ring with a fluorine atom attached to the para position (4th position) is present at the third carbon of the indole core.

Methyl group

Attached to the fifth carbon atom A methyl group (one carbon and three hydrogen atoms) is attached to the fifth carbon of the indole core.

Pharmaceutical research and drug development

Synthesis of potential therapeutic agents 1H-Indole, 3-(4-fluorophenyl)-5-methyl- is commonly used in the synthesis of potential drugs for various medical conditions due to its unique structure and properties.

Building block for novel molecules

Potential biological activity The structure and properties of 1H-Indole, 3-(4-fluorophenyl)-5-methylmake it a valuable component for creating new molecules with potential biological activity, making it a useful tool in medicinal chemistry and drug discovery.

Upstream product

• 637-60-5 p-tolylhydrazine hydrochloride 
• 1736-67-0 4-fluorophenylacetaldehyde 
• 614-96-0 5-methyl-1H-indole 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 141327-54-0 methyl 5-methyl-3-(4-fluorophenyl)-1H-indole-2-carboxylate 

Downstream Products

• 141307-00-8 1-amino-3-(4-fluorophenyl)-5-methyl-1H-indole 
• 1331947-56-8 3-(4-fluorophenyl)-5-methylindoline 
• 1331947-57-9 3-(4-fluorophenyl)-5-methyl-1-nitrosoindoline 
• 1331947-58-0 3-(4-fluorophenyl)-5-methyl-N-(propan-2-ylidene)indolin-1-amine 
• 141306-36-7 1-<2-<4-<3-(4-fluorophenyl)-5-methyl-1H-indol-1-yl>-1-piperidinyl>ethyl>-3-(2-propyl)-2-imidazolidinone 
• 141306-35-6 1-<2-<4-<3-(4-fluorophenyl)-5-methyl-1H-indol-1-yl>-1-piperidinyl>ethyl>-2-imidazolidinone 
• 141307-03-1 3-(4-fluorophenyl)-5-methyl-1-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole 
• 141306-22-1 3-(4-fluorophenyl)-5-methyl-1-(4-piperidyl)-1H-indole 
• 141306-14-1 3-(4-fluorophenyl)-5-methyl-1-(4-pyridinyl)-1H-indole 

Relevant academic research and scientific papers

Synthesis and antimycobacterial activity of 3-phenyl-1h-indoles

Tuberculosis has been described as a global health crisis since the 1990s, with an estimated 1.4 million deaths in the last year. Herein, a series of 20 1H-indoles were synthesized and evaluated as in vitro inhibitors of Mycobacterium tuberculosis (Mtb) g

Structure Ligation Relationship of Amino Acids for the Selective Indole C?H Arylation Reaction: L-Aspartic acid as Sustainable Alternative of Phosphine Ligands

The Structure Ligation Relationship (SLR) of free amino acids (AAs) under Pd-catalysis were examined for the chemo- and regio-selective indole C?H arylation reactions. While the majority of AAs were minor or ineffective, the L-aspartic acid (L-Asp) stands out promising to deliver high-value C3-arylated indoles with excellent chemo- (C vs N) and regioselectivity (C3 vs C2) with high functional group tolerance. Thus, the protocol offers a cost-effective and sustainable alternative of phosphine-based ligands for the indole C3?H arylation reactions. Preliminary mechanistic investigations suggested the simultaneous involvement of ?NH2, α-CO2H, and β-CO2H functionalities of L-Asp and found critical for its ligation efficiency. The developed catalytic system was compatible with the tandem decarboxylation/arylation procedure for the chemoselective synthesis of 3-aryl indoles. (Figure presented.).

FUSED TETRACYCLIC PYRIDO[4,3-B]INDOLE AND PYRIDO[3,4-B]ONDOLE DERIVATIVES AND METHODS OF USE

This disclosure is directed to fused tetracyclic pyrido[4,3-b]indoles and pyrido[3,4- b]indoles. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

3-ARYLINDOLE COMPOUNDS

3-Arylindole or 3-arylindazole derivatives having formula: STR1 wherein Ar is optionally substituted phenyl or a heteroaromatic group; R. sup.1-R 4 are independently selected from hydrogen, halogen, alkyl, alkoxy, hydroxy, nitro, alkylthio, alkylsulphonyl

Selective, Centrally Acting Serotonin 5-HT2 Antagonists. 2. Substituted 3-(4-Fluorophenyl)-1H-indoles

A series of 3-(4-fluorophenyl)-1H-indoles substituted in the 1-position with 4-piperidinyl, 1,2,3,6-tetrahydro-4-pyridinyl, and 4-piperazinyl was synthesized. By variation of the substituents in the benzene part of the indole nucleus in 1-2-4-3-(4-fluo