141306-12-9 Usage
Chemical Class
Indole
Molecular Structure
A tricyclic aromatic ring system with a flat structure, containing a nitrogen atom and a side chain with a fluorophenyl group at position 3 and a trifluoromethyl group at position 5.
Target
Epidermal Growth Factor Receptor (EGFR)
Mechanism of Action
Potent and selective inhibitor of EGFR, blocking the EGFR signaling pathway which plays a critical role in the proliferation and survival of cancer cells.
Anti-Cancer Activity
Has shown promising anti-cancer activity, particularly in the treatment of breast cancer.
Potential Therapeutic Use
Being studied as a potential therapeutic agent for the treatment of various types of cancer.
Field of Interest
Oncology research.
Check Digit Verification of cas no
The CAS Registry Mumber 141306-12-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,3,0 and 6 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 141306-12:
(8*1)+(7*4)+(6*1)+(5*3)+(4*0)+(3*6)+(2*1)+(1*2)=79
79 % 10 = 9
So 141306-12-9 is a valid CAS Registry Number.
141306-12-9Relevant academic research and scientific papers
3-ARYLINDOLE COMPOUNDS
-
, (2008/06/13)
3-Arylindole or 3-arylindazole derivatives having formula: STR1 wherein Ar is optionally substituted phenyl or a heteroaromatic group; R. sup.1-R 4 are independently selected from hydrogen, halogen, alkyl, alkoxy, hydroxy, nitro, alkylthio, alkylsulphonyl
Selective, Centrally Acting Serotonin 5-HT2 Antagonists. 2. Substituted 3-(4-Fluorophenyl)-1H-indoles
Andersen, Kim,Perregaard, Jens,Arnt, Joern,Nielsen, Joern Bay,Begtrup, Mikael
, p. 4823 - 4831 (2007/10/02)
A series of 3-(4-fluorophenyl)-1H-indoles substituted in the 1-position with 4-piperidinyl, 1,2,3,6-tetrahydro-4-pyridinyl, and 4-piperazinyl was synthesized. By variation of the substituents in the benzene part of the indole nucleus in 1-2-4-3-(4-fluo
