1413282-16-2

Upstream product

• 198969-39-0 5-O-benzyl-2,3-O-isopropylidene-D-ribofuranose 

Downstream Products

• 1413282-11-7 (((3aS,4R,6R,6aR)-6-((benzyloxy)methyl)-2,2-dimethyl-4-((2-nitrophenyl)ethynyl)-tetrahydrofuro[3,4-d][1,3]dioxol-3a-yl)-methoxy)(tert-butyl)dimethylsilane 
• 1413282-10-6 2-((3aS,4S,6R,6aR)-6-((benzyloxy)methyl)-3a-(((tertbutyldimethylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro-[3,4-d][1,3]dioxol-4-yl)-3-oxo-3H-indole 1-oxide 
• 1413282-18-4 ((3aS,4S,6R,6aR)-6-((benzyloxy)methyl)-2,2-dimethyl-4-((2-nitrophenyl)ethynyl)-tetrahydrofuro[3,4-d][1,3]dioxol-3a-yl)methanol 
• 1413282-19-5 ((3aS,4S,6R,6aR)-6-((benzyloxy)methyl)-2,2-dimethyl-4-((2-nitrophenyl)ethynyl)-tetrahydrofuro[3,4-d][1,3]dioxol-3a-yl)methyl acetate 
• 1413282-20-8 2-((3aS,4S,6R,6aR)-6-((benzyloxy)methyl)-3a-(acetoxymethyl)-2,2-dimethyltetrahydrofuro-[3,4-d][1,3]dioxol-4-yl)-3-oxo-3H-indole 1-oxide 
• 1413282-09-3 (S)-2-((3aS,4S,6R,6aR)-6-((benzyloxy)methyl)-3a-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-(1H-indol-3-yl)indolin-3-one 
• 1413282-12-8 (((3aS,4R,6R,6aR)-6-((benzyloxy)methyl)-4-ethynyl-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-3a-yl)methoxy)(tert-butyl)dimethylsilane 
• 1413282-22-0 (((3aS,4S,6R,6aR)-6-((benzyloxy)methyl)-4-ethynyl-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-3a-yl)methoxy)(tert-butyl)dimethylsilane 
• 1413282-17-3 ((3aS,4S,6R,6aR)-6-((benzyloxy)methyl)-4-ethynyl-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-3a-yl)methanol 
• 1413282-23-1 ((3aS,4R,6R,6aR)-6-((benzyloxy)methyl)-4-ethynyl-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-3a-yl)methanol 

Relevant academic research and scientific papers

Total synthesis of (-)-isatisine A

A modular total synthesis of (-)-isatisine A is described in which four consecutive metal-mediated transformations have been employed at the final stage. These include [Pd]-catalyzed Sonogashira coupling, [Pd]-catalyzed nitroalkyne cycloisomerization leading to isatogens, and addition of indoles to isatogens using InCl3-and [Rh]-catalyzed oxidative N-heterocyclization of amino alcohol to form the key amide bond. In addition to these, the removal of the protecting groups has also been carried out in a selective fashion employing either catalytic or stoichiometric metal/metal-based reagents.