141332-75-4

Upstream product

• 141333-36-0 4-cyanomethyl-2-cyclopentyloxy-1-methoxybenzene 
• 621-59-0 isovanillin 
• 137-43-9 Cyclopentyl bromide 
• 175206-66-3 4-chloromethyl-2-cyclopentyloxy-1-methoxybenzene 
• 133332-49-7 (3-cyclopentyloxy-4-methoxyphenyl)methanol 
• 67387-76-2 3-cyclopentyloxy-4-methoxybenzylaldehyde 
• 133332-47-5 2-(cyclopentyloxy)-1-methoxy-4-[(E)-2-nitroethenyl]benzene 

Downstream Products

• 141333-32-6 (3-cyclopentyloxy-4-methoxy)phenylacetaldehyde oxime 
• 141332-76-5 Methyl-N-[2-(3-Cyclopentyloxy-4-methoxyphenyl)ethyl]oxamate 
• 161918-67-8 N-[2-(3-cyclopentyloxy-4-methoxyphenyl)ethyl]oxamide 
• 471-46-5 Oxalamide 
• 569342-91-2 2-benzenesulfonyl-N-[2-(3-cyclopentyloxy-4-methoxyphenyl)ethyl]-2-diazo-N-(2,4,6-trimethylbenzyl)acetamide 
• 569342-90-1 2-benzenesulfonyl-N-[2-(3-cyclopentyloxy-4-methoxy-phenyl)-ethyl]-N-(2,4,6-trimethyl-benzyl)-acetamide 
• 569342-89-8 [2-(3-cyclopentyloxy-4-methoxyphenyl)ethyl]-(2,4,6-trimethylbenzyl)amine 
• 61413-54-5 Rolipram 
• 141333-62-2 [2-(3-cyclopentyloxy-4-methoxy-phenyl)-ethyl]-(4-nitro-phenyl)-amine 
• 256399-05-0 N-2-(3-Cyclopentyloxy-4-methoxyphenyl)ethyl-N-4-nitrophenyl-α-methoxycarbonyl-α-diazoacetamide 
• 256399-04-9 N-[2-(3-cyclopentyloxy-4-methoxy-phenyl)-ethyl]-N-(4-nitro-phenyl)-malonamic acid methyl ester 

Relevant academic research and scientific papers

Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors.

This communication describes the synthesis and in vitro PDE4 inhibitory activity of a novel series of imidazol-2-one and 2-cyanoiminoimidazole derivatives. The compounds described were also tested in in vivo models to evaluate their anti-inflammatory activity after topical administration as well as their gastro-intestinal side effects. Several compounds proved to be potent PDE4 inhibitors and some 2-cyanoiminoimidazoles showed less pronounced gastro-intestinal side effects than reference compounds but maintained anti-inflammatory activity after topical administration.

Catalytic enantioselective synthesis of the phosphodiesterase type IV inhibitor (R)-(-)-rolipram via intramolecular C-H insertion process

A new route to the phosphodiesterase type IV inhibitor (R)-(-)-rolipram (1) has been developed, wherein the key step relies on enantioselective intramolecular C-H insertion of N-alkyl-N-4-nitrophenyl-α-methoxycarbonyl- α-diazoacetamide 7 catalyzed by chir

PHENETHYLAMINE COMPOUNDS

Substituted phenethylamines of formula (I) useful for treating phosphodiesterase IV related disease states are disclosed herein.

PHENYLALKYL OXAMIDES

Novel oxamide derivatives are described which inhibit the production of TNF and are useful in the treatment of disease states mediated or exacerbated by TNF production. The compounds of the present invention are also useful as inhibitors of PDE IV and are therefor useful in the treatment of disease states mediated or exacerbated thereby