1413399-71-9

Upstream product

• 1413399-62-8 (R)-1-allyl-2-((S)-(benzhydryloxy)((R)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)piperidine 
• 1413399-85-5 (S)-6-((S)-(benzhydryloxy)((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-methyl)tetrahydro-2H-pyran-2-one 
• 107751-36-0 (S)-6-((S)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(hydroxy)methyl)tetrahydro-2H-pyran-2-one 
• 1413399-65-1 C₂₄H₃₁NO₅ 
• 1413399-58-2 (S)-2-((S)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(hydroxy)methyl)cyclopentanone 
• 120-92-3 cyclopentanone 
• 1119-51-3 bromopentene 
• 1413399-55-9 (2R,3R,4R,5R)-3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-5-(pent-4-en-1-yl)pyrrolidin-1-ol 
• 1413399-68-4 (3S,4S,4aR)-3-allyl-4-(benzhydryloxy)hexahydropyrido[1,2-c][1,3]oxazin-1(3H)-one 
• 1413399-57-1 1-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-5-(pent-4-en-1-yl)pyrrolidin-1-yl)ethanone 
• 1413399-67-3 (R)-ethyl 2-((S)-(benzhydryloxy)((S)-oxiran-2-yl)methyl)piperidine-1-carboxylate 
• 1413399-64-0 (R)-ethyl 2-((S)-(benzhydryloxy)((R)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)piperidine-1-carboxylate 

Relevant academic research and scientific papers

Total synthesis and glycosidase inhibition of broussonetine i and J 2

The first total synthesis of both broussonetine I and J2 together with their enantiomers have been accomplished via the same synthetic route through 18 and 16 steps in excellent overall yields (18% and 19%, respectively), starting from R-glyceraldehyde. Broussonetine I was found to be a potent inhibitor of β-glucosidase (IC50 = 2.9 μM), while ent-broussonetine I and ent-broussonetine J2 were found to be potent inhibitors of α-glucosidase (IC50 = 0.33 and 0.53 μM, respectively).