1413399-76-4

Upstream product

• 120-92-3 cyclopentanone 
• 5350-57-2 benzophenone hydrazone 
• 129694-18-4 (R)-6-((R)-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)(hydroxy)methyl)tetrahydro-2H-pyran-2-one 
• 22323-80-4 (4S)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde 
• 1413399-74-2 (R)-2-((R)-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)(hydroxy)methyl)cyclopentanone 

Downstream Products

• 1413399-77-5 (S)-1-allyl-2-((R)-(benzhydryloxy)((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)piperidine 
• 1413399-80-0 (3R,4R,4aS)-3-allyl-4-(benzhydryloxy)hexahydropyrido[1,2-c][1,3]oxazin-1(3H)-one 

Relevant academic research and scientific papers

Total synthesis and glycosidase inhibition of broussonetine i and J 2

The first total synthesis of both broussonetine I and J2 together with their enantiomers have been accomplished via the same synthetic route through 18 and 16 steps in excellent overall yields (18% and 19%, respectively), starting from R-glyceraldehyde. Broussonetine I was found to be a potent inhibitor of β-glucosidase (IC50 = 2.9 μM), while ent-broussonetine I and ent-broussonetine J2 were found to be potent inhibitors of α-glucosidase (IC50 = 0.33 and 0.53 μM, respectively).