1413441-91-4

Basic information

• Product Name: (E,E)-4,6-bis(4-(benzyloxy)styryl)-2-hydroxy-pyrimidine
• Synonyms: (E,E)-4,6-bis(4-(benzyloxy)styryl)-2-hydroxy-pyrimidine
• CAS NO: 1413441-91-4
• Molecular Weight: 512.608
• Mol File: 1413441-91-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E,E)-4,6-bis(4-(benzyloxy)styryl)-2-hydroxy-pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: (E,E)-4,6-bis(4-(benzyloxy)styryl)-2-hydroxy-pyrimidine(1413441-91-4)
• EPA Substance Registry System: (E,E)-4,6-bis(4-(benzyloxy)styryl)-2-hydroxy-pyrimidine(1413441-91-4)

Safety Data

• Hazardous Substances Data: 1413441-91-4(Hazardous Substances Data)

Upstream product

• 4397-53-9 p-benzyloxybenzaldehyde 
• 34289-60-6 4,6-dimethyl-2-hydroxy-pyrimidine hydrochloride 

Downstream Products

• 1413441-88-9 C₄₈H₄₆N₂O₁₂ 
• 1413441-83-4 (E,E)-4,6-bis(4-(benzyloxy)styryl)-2-D-glucopyranosyloxy-pyrimidine 

Relevant articles and documents

Synthesis of a novel series of (E, E)-4,6-bis(styryl)-2-O-glucopyranosyl- pyrimidines and their potent multidrug resistance (MDR) reversal activity against cancer cells

A novel series of methoxy or benzyloxy substituted (E,E)-4,6-bis(styryl)-2- O-glucopyranosyl-pyrimidines as curcuminoid analogs were synthesized in four steps with total yields of 21.5% to 33.9%. A549 and HL60 cells were employed for the anticancer activity testing. The results demonstrated that 5a, 5c, and 5e have some inhibitory activity against the HL-60 cell line. Unfortunately, no compound displayed inhibitory activity against A549 except for 5c. MDR reversal activity results demonstrated that compounds 4a (RF = 12.3) and 4b (RF = 18.5) showed strong reversal activity to the P-gp-mediated LCC6MDR cells compared to verapamil (RF = 3.2) and no cytotoxicity to cancer or normal cell lines even at a high concentrations (100M).