141362-06-3

Basic information

• Product Name: Benzene, 1-fluoro-4-(methoxymethoxy)-
• Synonyms: Benzene,1-fluoro-4-(methoxymethoxy);4-(methoxymethoxy)fluorobenzene;4-fluorophenyl methoxymethyl ether
• CAS NO: 141362-06-3
• Molecular Formula: C8H9FO2
• Molecular Weight: 156.157
• Mol File: 141362-06-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzene, 1-fluoro-4-(methoxymethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-fluoro-4-(methoxymethoxy)-(141362-06-3)
• EPA Substance Registry System: Benzene, 1-fluoro-4-(methoxymethoxy)-(141362-06-3)

Safety Data

• Hazardous Substances Data: 141362-06-3(Hazardous Substances Data)

Upstream product

• 371-41-5 4-Fluorophenol 
• 107-30-2 chloromethyl methyl ether 
• 109-87-5 Dimethoxymethane 

Downstream Products

• 264259-03-2 2-(diisopropylphosphanyl)-4-fluorophenol 
• 368422-23-5 5-fluoro-2-(methoxymethoxy)benzoic acid 
• 368422-25-7 2-fluoro-5-(methoxymethoxy)benzoic acid 
• 658707-34-7 2-(diphenylphosphanyl)-4-fluorophenyl methoxymethyl ether 
• 936250-15-6 1-(methoxymethoxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene 
• 148522-71-8 1-(5-fluoro-2-hydroxyphenyl)phenanthrene 
• 146746-54-5 9-(5-fluoro-2-hydroxyphenyl)phenanthrene triflate 
• 146746-53-4 9-(5-fluoro-2-hydroxyphenyl)phenanthrene 
• 125811-13-4 6-fluorobenzofluoranthrene 
• 51446-30-1 2-fluoro-5-hydroxybenzoic acid 
• 345-16-4 5-fluoro-2-hydroxybenzoic acid 
• 658707-37-0 2-(diisopropylphosphanyl)-4-fluorophenyl methoxymethyl ether 
• 1062515-68-7 1-<5-fluoro-2-(methoxymethoxy)phenyl>phenanthrene 
• 141362-10-9 9-<5-fluoro-2-(methoxymethoxy)phenyl>phenanthrene 

Relevant articles and documents

Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C-F Bond Functionalizations

Ni/Cu-catalyzed transformation of fluoroarenes to arylboronic acid pinacol esters via C-F bond cleavage has been achieved. Further versatile derivatization of an arylboronic ester has allowed for the facile two-step conversion of a fluoroarene to diverse functionalized arenes, demonstrating the synthetic utility of the method.

Fluorophenols and (trifluoromethyl)phenols as substrates of site-selective metalation reactions: To protect or not to protect

O-Methoxymethyl (MOM) protected fluorophenols can be cleanly metalated and subsequently be submitted to site-selective electrophilic substitution. The 2- and 4-isomers exhibit ambivalent reactivity: deprotonation occurs at the position adjacent to the oxygen when butyllithium is employed whereas the position adjacent to the fluorine is attacked by the superbasic mixture of butyllithium and potassium tert-butoxide (LIC-KOR). The MOM-protected (trifluoromethyl)-phenols react exclusively at oxygen-neighboring positions. The meta isomer provides another example of optional site selectivity, undergoing hydrogen/metal exchange at the 2-position with the LIC-KOR reagent and at the 6-position with sec-butyllithium. Unprotected (trifluoromethyl)phenols can also be ortho-metalated after O-deprotonation, although the products are formed in only moderate yields.