141389-79-9Relevant academic research and scientific papers
Synthesis of 3',4'-C-bishydroxymethyl-2',3',4'-trideoxy-β-L-threo- pentopyranosyl nucleosides as potential inhibitors of HIV
Lundquist,Kvarnstrom,Svensson,Classon,Samuelsson
, p. 1493 - 1502 (2007/10/02)
The synthesis of 3',4'-bishydroxymethyl-2',3',4'-trideoxy pentopyranosyl derivatives of thymine, uracil, cytosine, and adenine is described. trans- (3S,4S)-Bis(methoxycarbonyl)cyclopentanone (3) was converted to 1-O-acetyl- 3,4-C-bis[(tert-butyldiphenylsiloxy)methyl]-2,3,4-trideoxy-α,β-L-threo- pentopyranose (6), which was subsequently condensed with the silylated purine and pyrimidine bases.
Synthesis of 2′,3′-dideoxycyclo-2′-pentenyl-3′-C-hydroxymethyl carbocyclic nucleoside analogues as potential anti-viral agents
Wachtmeister, Johanna,Classon, Bjoern,Samuelsson, Bertil,Kvarnstroem, Ingmar
, p. 2029 - 2038 (2007/10/02)
The synthesis of optically pure unsaturated carbocyclic nucleoside analogues is described. (3,4S)-Bis(t-butyldiphenylsilyloxymethyl)-2-cyclopenten-1R and 1S-ol were coupled with 6-chloropurine and 2-amino-6-chloropurine respectively, using a modified Mits
Synthesis of novel olefinic carbocyclic purine nucleoside analogues
Wachtmeister,Classon,Samuelsson,Kvarnstrom
, p. 405 - 408 (2007/10/02)
The synthesis of optically pure unsaturated carbocyclic nucleoside analogues is described. (3,4S)-Bis(t-butyldiphenyl silyloxymethyl)-1R and 1S cyclopent-2-en-1-ol were coupled with 6 chloropurine and 2-amino-6- chloropurine respectively, using a modified
