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1413930-91-2

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1413930-91-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1413930-91-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,1,3,9,3 and 0 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1413930-91:
(9*1)+(8*4)+(7*1)+(6*3)+(5*9)+(4*3)+(3*0)+(2*9)+(1*1)=142
142 % 10 = 2
So 1413930-91-2 is a valid CAS Registry Number.

1413930-91-2Downstream Products

1413930-91-2Relevant articles and documents

Selected C7-substituted chromone derivatives as monoamine oxidase inhibitors

Legoabe, Lesetja J.,Petzer, Anél,Petzer, Jacobus P.

, p. 1 - 11 (2012)

A series of C7-substituted chromone (1-benzopyran-4-one) derivatives were synthesized and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The chromones are structurally related to a series of C7-functionalized coumarin (1-benzopyran-2-one) derivatives which has been reported to act as potent MAO inhibitors. The results of the current study document that the chromones are highly potent reversible inhibitors of MAO-B with IC50 values ranging from 0.008 to 0.370 μM. While the chromone derivatives also exhibit affinities for MAO-A, with IC50 values ranging from 0.495 to 8.03 μM, they are selective for the MAO-B isoform. Structure-activity relationships (SAR) show that 7-benzyloxy substitution of chromone is suitable for MAO-B inhibition with tolerance for a variety of substituents and substitution patterns on the benzyloxy ring. It may be concluded that 7-benzyloxychromones are appropriate lead compounds for the design of reversible and selective MAO-B inhibitors. With the aid of modeling studies, potential binding orientations and interactions of selected chromone derivatives in the MAO-A and -B active sites are examined.

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