141409-82-7Relevant academic research and scientific papers
Synthesis of N-(amidomethyl)- and N-(imidomethyl)-α-amino acid esters by reactions of α-amino acid esters with formaldehyde and amides or imides
Zlotin,Sharova,Luk'yanov
, p. 1670 - 1679 (1996)
Reactions of hydrochlorides of glycine, alanine, phenylalanine, L-isoleucine, and L-valine esters with aromatic and heteroaromatic carboxamides afforded hydrochlorides of the corresponding N-(amidomethyl)-α-amino acid esters. N-(Phthalimidomethyl)-α-amino acid esters were obtained by reactions of α-amino acid esters containing free amino groups with formaldehyde and phthalimide. The 1H NMR studies demonstrated that the chiral centers of α-amino acids may be retained in the course of condensation. Reactions of the Mannich bases obtained and their hydrochlorides with acetic anhydride and tosyl chloride afforded the corresponding N-acyl and N-sulfonyl derivatives.
A convenient and clean synthesis of methylenebisamides and carbinolamides over zeolites in aqueous media
Mameda, Naresh,Marri, Mahender Reddy,Peraka, Swamy,Macharla, Arun Kumar,Kodumuri, Srujana,Chevella, Durgaiah,Naresh, Gutta,Nama, Narender
, p. 41 - 43 (2015/02/02)
A simple, efficient and environmentally benign protocol for the synthesis of methylenebisamides and carbinolamides in high yields from aromatic amides and formaldehyde in the presence of heterogeneous catalysts (Hβ and NaY zeolites) using water as a solvent is demonstrated. Moreover, the catalyst is recyclable and can be reused without significant loss in its catalytic activity.
Imidazopyridazines. X. Syntheses and Central Nervous System Activities of Some 3-(Acetamido, benzamido, substituted benzamido or dimethylamino)methyl-2-(phenyl or substituted phenyl)-6-(halogeno, alkylthio, alkoxy, phenylthio, phenoxy, benzylthio o
Barlin, Gordon B.,Davies, Les P.,Ireland, Stephen J.,Ngu, Maria M. L.,Zhang, Jiankuo
, p. 731 - 749 (2007/10/02)
Syntheses of some 3-(acetamido, benzamido, substituted benzamido or dimethylamino)methyl-2-(phenyl or substituted phenyl)-6-(halogeno, alkylthio, alkoxy, phenylthio, phenoxy, benzylthio or benzyloxy)imidazopyridazines from the 3-unsubstituted analo
