141410-04-0

Basic information

• Product Name: (S)-α,α-diphenyl-(indolin-2-yl)methanol
• Synonyms: (S)-α,α-diphenyl-(indolin-2-yl)methanol
• CAS NO: 141410-04-0
• Molecular Weight: 301.388
• Mol File: 141410-04-0.mol

Chemical Properties

• CAS DataBase Reference: (S)-α,α-diphenyl-(indolin-2-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-α,α-diphenyl-(indolin-2-yl)methanol(141410-04-0)
• EPA Substance Registry System: (S)-α,α-diphenyl-(indolin-2-yl)methanol(141410-04-0)

Safety Data

• Hazardous Substances Data: 141410-04-0(Hazardous Substances Data)

Upstream product

• 141410-06-2 (S)-indoline-2-carboxylic acid methyl ester 
• 79815-20-6 (S)-indoline-2-carboxylic acid 
• 197460-37-0 (S)-tert-butyl 2-(hydroxydiphenylmethyl)indoline-1-carboxylate 
• 197460-36-9 methyl (S)-N-(tert-butoxycarbonyl)indoline-2-carboxylate 

Downstream Products

• 234079-72-2 (1R,2R,4R)-Bicyclo[2.2.1]hept-5-en-2-yl-[(S)-2-(hydroxy-diphenyl-methyl)-2,3-dihydro-indol-1-yl]-methanone 

Relevant articles and documents

ENANTIOSELECTIVE CATALYTIC BORANE REDUCTIONS OF ACHIRAL KETONES: SYNTHESES AND APPLICATION OF TWO CHIRAL β-AMINO ALCOHOLS FROM (S)-2-INDOLINE CARBOXYLIC ACID

The synthesis of (S)-α,α-diphenyl-(indolin-2-yl)methanol 1 makes available the chiral oxazaborolidine 2 which is an excellent catalyst for borane reduction of prochiral ketones to chiral secondary alcohols, e.g. acetophenone, in high optical purity.The ne

Enantioselective Reformatsky Reaction of Ketones Catalyzed by Chiral Indolinylmethanol

A reliable and practical Reformatsky reaction of ethyl iodide acetate with ketones for the synthesis of chiral β-hydroxyl carbonyl compounds in good yields and excellent enantioselectivities is presented. A readily available dihydroindole derivative was u

Organocatalyzed regioselective and enantioselective synthesis of 1,4- and 1,2-dihydropyridines

Herein, we introduce one of the first examples of asymmetric organocatalyzed synthesis of 1,2-dihydropyridines, affording enantioselective access to and partially solving regioselectivity challenges in the synthesis of dihydropyridines. We demonstrate that through modification of organocatalysts both 1,2- and 1,4-dihydropyridines (1,2- and 1,4-DHPs) can be obtained with high regioselectivity (ratio of 1,2-DHP/1,4-DHP from 95/5 to 0/100) and enantioselectivity (33% ee for 1,2-DHPs and up to 98% ee for 1,4-DHPs) in good yields (up to 87%).

Highly efficient asymmetric michael reaction of aldehydes to nitroalkenes with diphenylperhydroindolinol silyl ethers as organocatalysts

New dihydroindole and perhydroindole derivatives were synthesized in good yields and evaluated as chiral catalysts in the asymmetric Michael reaction of aldehydes to nitroalkenes. (2S,3aS,7aS)Diphenylperhydroindolinol silyl ether 10 facilitated the reacti

Dual enantioselective Diels-Alder process in the cyclization of chiral acrylamide with dienes

Diels-Alder cycloadditions of chiral acrylamides with cyclopentadiene or 2, 3-dimethyl butadiene proceed with high diastereofacial selectivity. Either endo-R or endo-S products have been obtained depending upon the structures of acrylamides and Lewis acids used. The endo form was exclusively obtained over the exo form. The dependence of the mechanism of formation of opposite configurations of endo-R or endo-S products on the Lewis acids is discussed. Copyright 2004 John Wiley & Sons, Ltd.