14142-16-6

Basic information

• Product Name: 2-methyl-1-phenylpiperidine
• Synonyms: Piperidine, 2-methyl-1-phenyl-
• CAS NO: 14142-16-6
• Molecular Formula: C₁₂H₁₇N
• Molecular Weight: 175.2701
• Mol File: 14142-16-6.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 267.5°C at 760 mmHg
• Flash Point: 105.7°C
• Density: 0.964g/cm³
• Vapor Pressure: 0.00812mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: 2-methyl-1-phenylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-1-phenylpiperidine(14142-16-6)
• EPA Substance Registry System: 2-methyl-1-phenylpiperidine(14142-16-6)

Safety Data

• Hazardous Substances Data: 14142-16-6(Hazardous Substances Data)

Upstream product

• 592-90-5 oxepane 
• 62-53-3 aniline 
• 86971-16-6 (+/-)-1-phenyl-2-<(phenylthio)methyl>piperidine 
• 629-11-8 1,6-hexanediol 
• 10141-72-7 2-methyloxane 
• 10226-29-6 6-Bromo-2-hexanone 
• 21856-89-3 6-hydroxy-2-hexanone 
• 3128-06-1 5-ketohexanoic acid 
• 446-52-6 2-Fluorobenzaldehyde 
• 109-05-7 2-Methylpiperidin 
• 130084-29-6 2-(2-methylpiperidin-1-yl)benzaldehyde 
• 98-95-3 nitrobenzene 
• 101-84-8 diphenylether 
• 108-86-1 bromobenzene 

Relevant articles and documents

Stoichiometric and Catalytic Inter- and Intramolecular Hydroamination of Terminal Alkynes by Frustrated Lewis Pairs

Frustrated Lewis pairs (FLPs) based on sterically encumbered anilines and the Lewis acid B(C6F5)3 were found to react with terminal alkynes effecting intermolecular hydroamination affording iminium alkynylborate species of the form [RPhN-C(R′)Me][R′CCB(C6F5)3]. In these cases, the reagent ratio of borane, aniline, and alkyne is 1:1:2. These reactions could also be performed in an intramolecular fashion by using anilines with alkynyl substituents effecting cyclization reactions. The use of 10mol % B(C6F5)3 under a H2 atmosphere provides a one-pot synthesis of the pyrrolidine 12, the piperidines 13-15, the azepane 16, the isoindoline 17, and the benzoxazine 18. Frustrated but satisfied: B(C6F5)3 was used to effect the stoichiometric and catalytic hydroamination of terminal alkynes by substituted anilines. Both inter- and intramolecular systems were explored in this reactivity. The mechanism adheres to previously observed frustrated Lewis pair reactivity.

Investigation towards the reductive amination of levulinic acid by B(C6F5)3/hydrosilane system

The selective transformation of the renewable biomass resources into the highly value-added platform chemicals is essentially important for sustainable chemistry. Here we report a simple and highly efficient strategy for the synthesis of N-heterocyclic co

Catalyst-free photodecarbonylation ofortho-amino benzaldehyde

It is almost a consensus that decarbonylation of the aldehyde group (-CHO) needs to not only be mediated by transition metal catalysts, but also requires severe reaction conditions (high temperature and long reaction time). In this work, inspired by the “conformational-selectivity-based” design strategy, we broke this consensus and discovered a catalyst-free photodecarbonylation of the aldehyde group. It revealed that decarbonylation can be easily achieved with visible light irradiation by introducing a tertiary amine into theortho-position of the aldehyde group. A diverse array of tertiary amines is tolerated by our photodecarbonylation under mild conditions. Furthermore, the (QM) computations of the mechanism and the experiments on well-designed special substrates revealed that our photodecarbonylation depends on the conformational specificity of the aldehyde group and tertiary amine, and occurs through an unusual [1,4]-H shift and a subsequent [1,3]-H shift.