141421-44-5

Basic information

• Product Name: 6-{2-[2-(trifluoromethyl)phenyl]ethyl}[1,3,4]thiadiazolo[3,2-a][1,2,3]triazolo[4,5-d]pyrimidin-9(2H)-one
• CAS NO: 141421-44-5
• Molecular Formula: C₁₄H₉F₃N₆OS
• Molecular Weight: 366.3211
• Mol File: 141421-44-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 548°C at 760 mmHg
• Flash Point: 285.2°C
• Density: 1.79g/cm³
• Vapor Pressure: 4.63E-12mmHg at 25°C
• Refractive Index: 1.771
• CAS DataBase Reference: 6-{2-[2-(trifluoromethyl)phenyl]ethyl}[1,3,4]thiadiazolo[3,2-a][1,2,3]triazolo[4,5-d]pyrimidin-9(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-{2-[2-(trifluoromethyl)phenyl]ethyl}[1,3,4]thiadiazolo[3,2-a][1,2,3]triazolo[4,5-d]pyrimidin-9(2H)-one(141421-44-5)
• EPA Substance Registry System: 6-{2-[2-(trifluoromethyl)phenyl]ethyl}[1,3,4]thiadiazolo[3,2-a][1,2,3]triazolo[4,5-d]pyrimidin-9(2H)-one(141421-44-5)

Safety Data

• Hazardous Substances Data: 141421-44-5(Hazardous Substances Data)

Upstream product

• 141422-12-0 7-Amino-6-nitro-2-[2-(2-trifluoromethyl-phenyl)-ethyl]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one 
• 141421-88-7 7-Hydroxy-6-nitro-2-[2-(2-trifluoromethyl-phenyl)-ethyl]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one 
• 141422-09-5 7-Chloro-6-nitro-2-[2-(2-trifluoromethyl-phenyl)-ethyl]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one 
• 141421-66-1 7-Hydroxy-2-[2-(2-trifluoromethyl-phenyl)-ethyl]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one 
• 141421-45-6 5-[2-(2-Trifluoromethyl-phenyl)-ethyl]-[1,3,4]thiadiazol-2-ylamine 

Relevant articles and documents

Synthesis and antiallergy activity of [1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one derivatives. I

A series of 6-substituted [1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one derivatives 4a-z were synthesized from 5-substituted-1,3,4-thiadiazol-2-amines 5 by the following consecutive reactions: pyrimidine ring closure with bis(2,4,6-trichlorophenyl) malonate, nitration, chlorination, amination, hydrogenation and diazotization. The structure of 4 was confirmed by an alternate synthesis of 4, involving reaction of 5-substituted 2-azido-1,3,4-thiadiazole 13 with ethyl cyanoacetate, followed by the Dimroth rearrangement and ring closure. The antiallergic activities (anti-passive peritoneal anaphylaxis, anti-passive cutaneous anaphylaxis and anti-slow reacting substance of anaphylaxis activities) of the products were evaluated.